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急性硫化氢中毒的病例系列与临床分析:舟山某医院10例病例经验

Case series and clinical analysis of acute hydrogen sulfide poisoning: Experience from 10 cases at a hospital in Zhoushan.

作者信息

Shen Yuechuan, Zhao Guangfen, Lin Jingkai, Wang Junyan, Luo Bin, Liu Jingye, Zhang Yini, Huang Junhua

机构信息

Department of Emergency, Zhoushan Hospital of Zhejiang Province, Zhoushan, China.

出版信息

Toxicol Ind Health. 2025 Mar;41(3):151-162. doi: 10.1177/07482337241308388. Epub 2024 Dec 20.

DOI:10.1177/07482337241308388
PMID:39704130
Abstract

This study investigated the etiology, clinical features, and management of acute hydrogen sulfide (HS) poisoning in Zhoushan. A retrospective analysis was conducted on 10 patients admitted to our hospital between August and September 2023 due to two incidents of acute HS poisoning. The first incident involved fishermen working in a fishing cabin (6 patients), while the second involved sanitation workers during sewer maintenance (4 patients). Among the patients, 4 had severe poisoning, 3 had moderate poisoning, and 3 had mild poisoning. Corneal chemical injuries were observed in 4 severe patients, and chest CT scans showed bilateral infiltrative changes in 7 patients. Elevated lactate concentrations, and low oxygenation indices were noted in all severe patients. Severe cases received intensive care, including tracheal intubation, mechanical ventilation, corticosteroids, methylene blue, ulinastatin, and hyperbaric oxygen therapy. Patients with mild to moderate symptoms received supportive treatments, including oxygen therapy and hyperbaric oxygen therapy. With the exception of one fatality, all other patients were discharged after successful treatment. Fishing boat cabins and decomposed sewage channels in island areas are common sites for acute HS poisoning. Rapid identification of HS poisoning and evaluation are crucial. Early airway management is essential for severe cases to prevent vital organ hypoxia.

摘要

本研究调查了舟山急性硫化氢(HS)中毒的病因、临床特征及治疗方法。对2023年8月至9月期间因两起急性HS中毒事件入住我院的10例患者进行了回顾性分析。第一起事件涉及在渔船船舱工作的渔民(6例患者),第二起事件涉及下水道维护期间的环卫工人(4例患者)。患者中,4例为重度中毒,3例为中度中毒,3例为轻度中毒。4例重度患者出现角膜化学伤,7例患者胸部CT扫描显示双侧浸润性改变。所有重度患者均出现乳酸浓度升高和氧合指数降低。重度病例接受了重症监护,包括气管插管、机械通气、皮质类固醇、亚甲蓝、乌司他丁和高压氧治疗。轻至中度症状患者接受了支持性治疗,包括氧疗和高压氧治疗。除1例死亡外,其他患者均治疗成功后出院。海岛地区的渔船船舱和污水分解渠道是急性HS中毒的常见场所。快速识别HS中毒并进行评估至关重要。对于重度病例,早期气道管理对于预防重要器官缺氧至关重要。

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Case series and clinical analysis of acute hydrogen sulfide poisoning: Experience from 10 cases at a hospital in Zhoushan.急性硫化氢中毒的病例系列与临床分析:舟山某医院10例病例经验
Toxicol Ind Health. 2025 Mar;41(3):151-162. doi: 10.1177/07482337241308388. Epub 2024 Dec 20.
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Neurological Sequelae of Acute Hydrogen Sulfide Poisoning: A Literature Review, Controversies, and Knowledge Gaps.急性硫化氢中毒的神经后遗症:文献综述、争议与知识空白
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