Baldawa Harsh, Ravindran Vignesh, Jeevanandan Ganesh, Arthanari Abirami, Teja Kavalipurapu Venkata, Spagnuolo Gianrico, Rengo Carlo, Iaculli Flavia, Cernera Mariangela
Department of Pediatric and Preventive Dentistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Department of Forensic Odontology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Eur Endod J. 2024 Dec;9(4):344-351. doi: 10.14744/eej.2024.53315.
To evaluate the effect of a newly developed MTA-based material and two antibacterial-enhanced MTAs as pulp capping materials in immature permanent dental elements underwent full pulpotomy.
The present animal study included 20 Wistar albino rats that, after full pulpotomy, were randomly divided into 4 groups receiving different MTA formulations as pulp capping materials: conventional MTA, Tricalcium aluminate (TCA)- free MTA, and MTA enhanced with metronidazole or doxycycline. Histopathological assessments were carried out at 7- and 28-days post-treatment to evaluate dentinal bridge formation, inflammatory reactions, pulp tissue necrosis and internal resorption.
Seven days post-treatment, all groups exhibited inflammation and pulp necrosis, that were minimal in Groups III and IV than Group I. Group II showed a statistically significant difference only in terms of pulp necrosis (p<0.001). At 28-days all Groups showed slight inflammation and pulp necrosis, mainly in Groups I. Dentinal bridge formation was appreciated in all samples belonging to Groups II, III and IV and in 7/10 specimens of Group I, resulting in a statistically significant difference (p≤0.001).
TCA-free MTA and antibiotic-enhanced MTAs showed superior performances in dentinal bridge formation and exhibited minimal pulpal necrosis than conventional MTA. The inclusion of antibiotics might contribute to create a more sterile environment that would improve the outcomes, favoring deposition of a mineralized matrix. However, further studies are needed to support these preliminary results. (EEJ-2024-10-157).
评估一种新开发的基于MTA的材料以及两种抗菌增强型MTA作为盖髓材料在未成熟恒牙进行全牙髓切断术后的效果。
本动物研究纳入了20只Wistar白化大鼠，在进行全牙髓切断术后，将其随机分为4组，分别接受不同的MTA配方作为盖髓材料：传统MTA、无铝酸三钙（TCA）的MTA以及用甲硝唑或强力霉素增强的MTA。在治疗后7天和28天进行组织病理学评估，以评估牙本质桥形成、炎症反应、牙髓组织坏死和内部吸收情况。
治疗后7天，所有组均出现炎症和牙髓坏死，其中第III组和第IV组的炎症和牙髓坏死程度低于第I组。第II组仅在牙髓坏死方面显示出统计学上的显著差异（p<0.001）。在28天时，所有组均表现出轻微炎症和牙髓坏死，主要在第I组。在属于第II组、第III组和第IV组的所有样本以及第I组的7/10个标本中均观察到牙本质桥形成，结果具有统计学上的显著差异（p≤0.001）。
无TCA的MTA和抗生素增强型MTA在牙本质桥形成方面表现出优异性能，并且与传统MTA相比，牙髓坏死程度最小。添加抗生素可能有助于营造一个更无菌的环境，从而改善治疗效果，有利于矿化基质的沉积。然而，需要进一步的研究来支持这些初步结果。（EEJ - 2024 - 10 - 157）
