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一种用于放射治疗的基于新型闪烁凝胶的三维剂量测定系统的开发与应用。

Development and application of a novel scintillation gel-based 3D dosimetry system for radiotherapy.

作者信息

Li Hua, Jin Haijing, He Liang, Yan Xuewen, Zhang Hui, Li Deyuan

机构信息

Frontier Technology Center, China Institute for Radiation Protection, Taiyuan, Shanxi, China.

Shanxi Provincial Key Laboratory for Translational Nuclear Medicine and Precision Protection, Taiyuan, Shanxi, China.

出版信息

J Appl Clin Med Phys. 2025 Mar;26(3):e14615. doi: 10.1002/acm2.14615. Epub 2024 Dec 20.

DOI:10.1002/acm2.14615
PMID:39704638
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11905255/
Abstract

PURPOSE

This study introduced a novel 3D dosimetry system for radiotherapy in order to address the limitations of traditional quality assurance methods in precision radiotherapy techniques.

METHODS

The research required the use of scintillation material, optical measurements, and a dose reconstruction algorithm. The scintillation material, which mimics human soft tissue characteristics, served as a both physical phantom and a radiation detector. The dose distribution inside the scintillator can be converted to light distributions, which were measured by optical cameras from different angles and manifested as pixel values. The proposed dose reconstruction algorithm, LASSO-TV, effectively reconstructed the dose distribution from pixel values, overcoming challenges such as limited projection directions and large-scale matrices.

RESULTS

Various clinical plans were tested and validated, including a modified segment from the SBRT plan and IMRT clinical plan. The dosimetry system can execute full 3D dose determinations as a function of time with a spatial resolution of 1-2 mm, enabling high-resolution measurements for dynamic dose distribution. Comparative analysis with mainstream device MapCHECK2 confirmed the accuracy of the system, with a relative measurement error of within 5%.

CONCLUSIONS

Testing and validation results demonstrated the dosimetry system's promising potential for dynamic treatment quality assurance.

摘要

目的

本研究引入了一种用于放射治疗的新型三维剂量测定系统，以解决传统质量保证方法在精确放射治疗技术中的局限性。

方法

该研究需要使用闪烁材料、光学测量和剂量重建算法。模拟人体软组织特征的闪烁材料既作为物理体模又作为辐射探测器。闪烁体内的剂量分布可转换为光分布，由光学相机从不同角度进行测量，并表现为像素值。所提出的剂量重建算法LASSO-TV能够从像素值有效地重建剂量分布，克服了投影方向有限和矩阵规模大等挑战。

结果

对各种临床计划进行了测试和验证，包括立体定向体部放疗计划的一个修改片段和调强放疗临床计划。该剂量测定系统能够以1-2毫米的空间分辨率根据时间进行完整的三维剂量测定，从而实现对动态剂量分布的高分辨率测量。与主流设备MapCHECK2的对比分析证实了该系统的准确性，相对测量误差在5%以内。

结论

测试和验证结果表明该剂量测定系统在动态治疗质量保证方面具有广阔的应用前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/eeca83f4d21a/ACM2-26-e14615-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/75d4c9bf196f/ACM2-26-e14615-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/c453667a1b6f/ACM2-26-e14615-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/660d6dc03da8/ACM2-26-e14615-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/ab94a6b85cad/ACM2-26-e14615-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/3206ef8e58f0/ACM2-26-e14615-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/c720fc8030e4/ACM2-26-e14615-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/a1563389c923/ACM2-26-e14615-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/1003a11f6b0e/ACM2-26-e14615-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/c8c77454b873/ACM2-26-e14615-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/854999ebdbec/ACM2-26-e14615-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/759e401fc686/ACM2-26-e14615-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/eeca83f4d21a/ACM2-26-e14615-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/75d4c9bf196f/ACM2-26-e14615-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/c453667a1b6f/ACM2-26-e14615-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/660d6dc03da8/ACM2-26-e14615-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/ab94a6b85cad/ACM2-26-e14615-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/3206ef8e58f0/ACM2-26-e14615-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/c720fc8030e4/ACM2-26-e14615-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/a1563389c923/ACM2-26-e14615-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/1003a11f6b0e/ACM2-26-e14615-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/c8c77454b873/ACM2-26-e14615-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/854999ebdbec/ACM2-26-e14615-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/759e401fc686/ACM2-26-e14615-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f9/11905255/eeca83f4d21a/ACM2-26-e14615-g007.jpg

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本文引用的文献

1
SU-E-T-116: The Water Equivalence of Organic Liquid Scintillators for Proton Dosimetry.SU-E-T-116：用于质子剂量测定的有机液体闪烁体的水等效性
Med Phys. 2012 Jun;39(6Part11):3729. doi: 10.1118/1.4735174.
2
Novel, full 3D scintillation dosimetry using a static plenoptic camera.使用静态全光相机的新型全三维闪烁剂量测定法。
Med Phys. 2014 Aug;41(8):082101. doi: 10.1118/1.4884036.
3
[Present situation and progress of dose verification in radiotherapy].[放射治疗中剂量验证的现状与进展]
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2013 Dec;30(6):1358-61.
4
The importance of accurate treatment planning, delivery, and dose verification.精确治疗计划、实施及剂量验证的重要性。
Rep Pract Oncol Radiother. 2012 Mar 6;17(2):63-5. doi: 10.1016/j.rpor.2012.02.001. eCollection 2012.
5
Optical artefact characterization and correction in volumetric scintillation dosimetry.体闪烁剂量学中的光学伪影特征描述与校正。
Phys Med Biol. 2014 Jan 6;59(1):23-42. doi: 10.1088/0031-9155/59/1/23. Epub 2013 Dec 10.
6
3D tomodosimetry using long scintillating fibers: a feasibility study.基于长闪烁光纤的三维剂量测定：一项可行性研究。
Med Phys. 2013 Oct;40(10):101703. doi: 10.1118/1.4819937.
7
Preliminary investigations on the determination of three-dimensional dose distributions using scintillator blocks and optical tomography.使用闪烁体块和光断层成像技术测定三维剂量分布的初步研究。
Med Phys. 2013 Aug;40(8):082104. doi: 10.1118/1.4813898.
8
Quenching correction for volumetric scintillation dosimetry of proton beams.用于质子束体闪烁剂量学的淬灭校正。
Phys Med Biol. 2013 Jan 21;58(2):261-73. doi: 10.1088/0031-9155/58/2/261. Epub 2012 Dec 21.
9
Verification of proton range, position, and intensity in IMPT with a 3D liquid scintillator detector system.利用 3D 液体闪烁探测器系统验证 IMPT 中的质子射程、位置和强度。
Med Phys. 2012 Mar;39(3):1239-46. doi: 10.1118/1.3681948.
10
Polymer gel dosimetry.高分子凝胶剂量测定法。
Phys Med Biol. 2010 Mar 7;55(5):R1-63. doi: 10.1088/0031-9155/55/5/R01. Epub 2010 Feb 11.