Huang Xiaofei, Xu Xiao, Zhou Luning, Ma Chuanteng, Wang Wenxue, Li Chen, Wang Jiaxiang, Zhang Guojian, Li Dehai, Che Qian, Zhu Tianjiao
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Sanya Oceanographic Institute, Ocean University of China, Qingdao 266003, People's Republic of China.
Laboratory for Marine Drugs and Bioproducts, Laoshan Laboratory, Qingdao 266237, People's Republic of China.
J Agric Food Chem. 2025 Jan 8;73(1):541-548. doi: 10.1021/acs.jafc.4c09101. Epub 2024 Dec 20.
, a common foodborne pathogen, has a close association with agriculture and food. With the rapid emergence and widespread dissemination of antimicrobial resistance, efforts have been directed toward developing and studying new antimicrobial compounds to inhibit the growth of and other foodborne pathogens, thereby preventing contamination and ensuring food safety. Herein, we reported eight new aromatic polyketides, naphpyrones A-H (-), from the heterologous expression strain A3(2)/ ΔH3. Their structures and absolute configurations were elucidated by extensive NMR, MS, theoretical NMR calculations, DP4+ probability analysis, Mosher's method, and ECD analyses. Notably, naphpyrone A () featured an unprecedented 6/6/6/6/5 neocyclic skeleton. Bioactivity evaluation revealed that compounds and exhibited antibacterial activity against , with MIC values of 1 μg/mL and 4 μg/mL, respectively. These findings highlight the potential for screening and developing therapeutic agents from -derived aromatic polyketides against food pathogens.
