Assaggaf Hamza Mohammad
Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Int J Biol Macromol. 2025 Feb;290:138873. doi: 10.1016/j.ijbiomac.2024.138873. Epub 2024 Dec 18.
Apium graveolens Linn., also known as celery, is a member of the Apiaceae family and has shown promising pharmacological properties, including diabetes. Indeed, the current investigation aimed to investigate the potential inhibitory effects of A. graveolens seed aqueous extract on the digestive enzymes involved in carbohydrate metabolism and its efficiency in reducing blood sugar levels in diabetic mice induced by streptozotocin.
I administered oral doses of an aqueous extract from A. graveolens seeds to both normal and diabetic animals to evaluate acute toxicity and its potential antidiabetic effects. I observed the glycemia and body weight of the animals for four weeks. In vitro tests were also done to see how the seed extract affected the activities of α-amylase and α-glucosidase. Following administration of the extract, diabetic mice showed a notable reduction in blood glucose concentration. This reduction was similar to the standard metformin treatment after two and four weeks. Moreover, A. graveolens demonstrated significant inhibitory effects on α-amylase and α-glucosidase activity, with IC values of 840.15 ± 0.02 and 114.81 ± 0.05, respectively. At 500 mg/kg/day, histological analysis indicated degenerative alterations in pancreatic islet cells. These results indicate that the aqueous extract derived from the seeds of A. graveolens possesses promising antihyperglycemic properties in diabetic mice, along with notable inhibition of α-amylase and α-glucosidase activity. Further investigation is needed to characterize the active compounds present in A. graveolens seeds.
旱芹，也被称为芹菜，是伞形科植物的一种，已显示出有前景的药理特性，包括对糖尿病的作用。事实上，当前的研究旨在探究旱芹种子水提取物对参与碳水化合物代谢的消化酶的潜在抑制作用，以及其在降低链脲佐菌素诱导的糖尿病小鼠血糖水平方面的效果。
我给正常和糖尿病动物口服旱芹种子水提取物，以评估其急性毒性及其潜在的抗糖尿病作用。我观察了动物四周的血糖水平和体重。还进行了体外试验，以观察种子提取物如何影响α-淀粉酶和α-葡萄糖苷酶的活性。给予提取物后，糖尿病小鼠的血糖浓度显著降低。在两周和四周后，这种降低与标准二甲双胍治疗相似。此外，旱芹对α-淀粉酶和α-葡萄糖苷酶活性表现出显著的抑制作用，IC值分别为840.15±0.02和114.81±0.05。在500毫克/千克/天的剂量下，组织学分析表明胰岛细胞有退行性改变。这些结果表明，旱芹种子水提取物在糖尿病小鼠中具有有前景的降血糖特性，同时对α-淀粉酶和α-葡萄糖苷酶活性有显著抑制作用。需要进一步研究来鉴定旱芹种子中存在的活性化合物。
