• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Insights into IVDD pathogenesis in 2024.

作者信息

Sakai Daisuke

机构信息

Department of Orthopedic Surgery, Surgical Science, Tokai University School of Medicine, Isehara, Japan.

出版信息

Nat Rev Rheumatol. 2025 Feb;21(2):71-72. doi: 10.1038/s41584-024-01207-4.

DOI:10.1038/s41584-024-01207-4
PMID:39706906
Abstract
摘要

相似文献

1
Insights into IVDD pathogenesis in 2024.2024年对椎间盘退变发病机制的见解。
Nat Rev Rheumatol. 2025 Feb;21(2):71-72. doi: 10.1038/s41584-024-01207-4.
2
Pyroptosis and Intervertebral Disc Degeneration: Mechanistic Insights and Therapeutic Implications.细胞焦亡与椎间盘退变：机制洞察与治疗意义
J Inflamm Res. 2022 Oct 17;15:5857-5871. doi: 10.2147/JIR.S382069. eCollection 2022.
3
The pathological mechanisms of circRNAs in mediating intervertebral disc degeneration.环状RNA介导椎间盘退变的病理机制
Noncoding RNA Res. 2023 Sep 18;8(4):633-640. doi: 10.1016/j.ncrna.2023.09.004. eCollection 2023 Dec.
4
Exploring the role of gut microbiota in intervertebral disc degeneration: insights from bidirectional Mendelian randomization analysis.探索肠道微生物群在椎间盘退变中的作用：双向孟德尔随机化分析的见解
Eur Spine J. 2025 Apr 21. doi: 10.1007/s00586-025-08794-0.
5
Causal relationship of interferon-γ and interleukin-18 upstream of intervertebral disc degeneration pathogenesis: a two-sample Mendelian randomization study.椎间盘退变发病机制上游中干扰素-γ与白细胞介素-18的因果关系：一项两样本孟德尔随机化研究
Front Neurol. 2024 Jun 19;15:1420942. doi: 10.3389/fneur.2024.1420942. eCollection 2024.
6
RBX1 mitigates ferroptosis by inhibiting NCOA4-mediated ferritinophagy and contributes to the attenuation of intervertebral disc degeneration.RBX1通过抑制NCOA4介导的铁自噬减轻铁死亡，并有助于减轻椎间盘退变。
J Transl Med. 2025 May 7;23(1):514. doi: 10.1186/s12967-025-06412-7.
7
Role of arachidonic acid metabolism in intervertebral disc degeneration: identification of potential biomarkers and therapeutic targets via multi-omics analysis and artificial intelligence strategies.花生四烯酸代谢在椎间盘退变中的作用：通过多组学分析和人工智能策略鉴定潜在的生物标志物和治疗靶点。
Lipids Health Dis. 2023 Nov 25;22(1):204. doi: 10.1186/s12944-023-01962-5.
8
LncRNA FAM83H-AS1 maintains intervertebral disc tissue homeostasis and attenuates inflammation-related pain via promoting nucleus pulposus cell growth through miR-22-3p inhibition.长链非编码RNA FAM83H-AS1通过抑制miR-22-3p促进髓核细胞生长，维持椎间盘组织稳态并减轻炎症相关疼痛。
Ann Transl Med. 2020 Nov;8(22):1518. doi: 10.21037/atm-20-7056.
9
CLEC11A-Driven Molecular Mechanisms in Intervertebral Disc Degeneration: A Comprehensive Multi-Omics Study.CLEC11A在椎间盘退变中的驱动分子机制：一项全面的多组学研究
J Inflamm Res. 2025 Jan 29;18:1353-1375. doi: 10.2147/JIR.S505296. eCollection 2025.
10
Role of ferroptosis and immune infiltration in intervertebral disc degeneration: novel insights from bioinformatics analyses.铁死亡和免疫浸润在椎间盘退变中的作用：来自生物信息学分析的新见解
Front Cell Dev Biol. 2023 Sep 6;11:1170758. doi: 10.3389/fcell.2023.1170758. eCollection 2023.

引用本文的文献

1
Tie2-mediated CBL ubiquitination of EGFR underlies ultrasound-responsive silk fibroin/graphene oxide hydrogel-troxerutin therapy for intervertebral disc degeneration.Tie2介导的EGFR的CBL泛素化是超声响应性丝素蛋白/氧化石墨烯水凝胶-曲克芦丁治疗椎间盘退变的基础。
Mater Today Bio. 2025 Jul 29;34:102149. doi: 10.1016/j.mtbio.2025.102149. eCollection 2025 Oct.
2
Correlation Analysis of Serum G-Protein-Coupled Receptor 4 and Biglycan Levels with the Severity of Intervertebral Disc Degeneration.血清G蛋白偶联受体4和双糖链蛋白聚糖水平与椎间盘退变严重程度的相关性分析
Orthop Res Rev. 2025 Jul 8;17:289-297. doi: 10.2147/ORR.S525337. eCollection 2025.
3

本文引用的文献

1
Nuclear factor κB overactivation in the intervertebral disc leads to macrophage recruitment and severe disc degeneration.核因子 κB 在椎间盘内的过度激活导致巨噬细胞募集和严重的椎间盘退变。
Sci Adv. 2024 Jun 7;10(23):eadj3194. doi: 10.1126/sciadv.adj3194.
2
Intervertebral disc microbiome in Modic changes: Lack of result replication underscores the need for a consensus in low-biomass microbiome analysis.莫迪克改变中的椎间盘微生物群：缺乏结果重复性凸显了低生物量微生物群分析中达成共识的必要性。
JOR Spine. 2024 Apr 4;7(2):e1330. doi: 10.1002/jsp2.1330. eCollection 2024 Jun.
3
Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration.
Precision prediction of intervertebral disc degeneration in ankylosing spondylitis using a nomogram model reveals the pivotal role of Th2-type immune dysregulation.
使用列线图模型对强直性脊柱炎椎间盘退变进行精准预测揭示了Th2型免疫失调的关键作用。
Front Immunol. 2025 May 12;16:1556738. doi: 10.3389/fimmu.2025.1556738. eCollection 2025.
晚期髓核细胞分泌的糖蛋白聚糖是椎间盘退变的生物标志物。
Nat Commun. 2024 Jan 2;15(1):47. doi: 10.1038/s41467-023-44313-9.
4
"Are we barking up the wrong tree? Too much emphasis on Cutibacterium acnes and ignoring other pathogens"- a study based on next-generation sequencing of normal and diseased discs.“我们是不是找错了方向？过于强调痤疮丙酸杆菌而忽略了其他病原体”——一项基于正常和病变椎间盘的下一代测序研究。
Spine J. 2023 Oct;23(10):1414-1426. doi: 10.1016/j.spinee.2023.06.396. Epub 2023 Jun 25.
5
Intervertebral disc degeneration and how it leads to low back pain.椎间盘退变及其如何导致腰痛。
JOR Spine. 2022 Nov 14;6(1):e1231. doi: 10.1002/jsp2.1231. eCollection 2023 Mar.
6
An in-depth analysis of the immunomodulatory mechanisms of intervertebral disc degeneration.椎间盘退变免疫调节机制的深入分析
JOR Spine. 2022 Dec 8;5(4):e1233. doi: 10.1002/jsp2.1233. eCollection 2022 Dec.
7
Prevalence of Propionibacterium acnes in Intervertebral Discs of Patients Undergoing Lumbar Microdiscectomy: A Prospective Cross-Sectional Study.腰椎间盘显微切除术患者椎间盘内痤疮丙酸杆菌的患病率：一项前瞻性横断面研究
PLoS One. 2016 Aug 18;11(8):e0161676. doi: 10.1371/journal.pone.0161676. eCollection 2016.