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Pyruvate prevents the ATP depletion caused by formaldehyde or calcium-chelator esters in the human red cell.

作者信息

García-Sancho J

出版信息

Biochim Biophys Acta. 1985 Feb 28;813(1):148-50. doi: 10.1016/0005-2736(85)90357-8.

DOI:10.1016/0005-2736(85)90357-8
PMID:3970916
Abstract

Formaldehyde released during hydrolysis of calcium-chelator esters incorporated into cells blocks glycolysis in the human erythrocyte (Tiffert, T., García-Sancho, J. and Lew, V.L. (1984) Biochim. Biophys. Acta 773, 143-156). This blockade is due to the inhibition of glyceraldehyde-3-phosphate dehydrogenase by NAD+ depletion caused by enzymatic oxidation of formaldehyde coupled to NADH production. The addition of pyruvate to the incubation medium prevents or reverts ATP depletion.

摘要

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