肥胖型肌少症患者人体测量学、身体能力和生理指标的非药物治疗策略：对严格随机对照试验的系统评价
Non-pharmacological treatment strategies for anthropometric, physical capacity and physiological indicators among sarcopenic obesity patients: a systematic review of rigorous randomized controlled trials.
作者信息
Tian Haodong, Li Hansen, Zhang Xing, Liu Haowei, Huang Li, Yu Hanglin, Wu Jinlong, Cao Yang, Peng Li, García-Ramos Amador
机构信息
College of Physical Education, Southwest University, Chongqing, China.
Key Laboratory of Physical Fitness Evaluation and Sports Function Monitoring of General Administration of Sport of China, Southwest University, Chongqing, China.
出版信息
Age Ageing. 2024 Nov 28;53(12). doi: 10.1093/ageing/afae278.
OBJECTIVES
To investigate the effects of non-pharmacological treatments on sarcopenic obesity (SO).
METHODS
A search for randomized controlled trials (RCTs) on SO was conducted in PubMed, Web of Science, CINAHL, CENTRAL, SPORTDiscus, CNKI, Wanfang and VIP. A meta-analysis was conducted using random-effects models for MDs.
RESULTS
The meta-analysis on 21 RCTs showed that exercise improved PBF (MD: -1.67%, p < .01, I2 = 35%), grip strength (MD: 2.2 kg, p = .03, I2 = 61%), GS (MD: 0.08 m/s, p = .02, I2 = 0%), TCR (MD: 2.22 repetitions, p < .01, I2 = 0%), TUG (MD: -1.48 s, p < .01, I2 = 61%), UE strength (MD: 1.88 kg/kg, p < .01, I2 = 0%) and LE strength (MD: 2.19 kg/kg, p < .01, I2 = 0%). Nutritional interventions improved grip strength (MD: 1.52 kg, p < .01, I2 = 0%). Combine interventions improved PBF (MD: -1.97%, p < .01, I2 = 38%), ASMM (MD: 0.4 kg, p < .01, I2 = 6%), grip strength (MD: 1.83 kg, p < .01, I2 = 38%) and GS (MD: 0.04 m/s, p < .01, I2 = 0%). Combined interventions were more effective than nutrition alone for reducing PBF (MD: -0.8%, p = .05, I2 = 0%).
CONCLUSION
The effects of exercise and nutrition interventions on SO are limited individually, especially regarding muscle mass, but their combination can yield optimal results. Additionally, physical therapy also demonstrated some potential.
目的
探讨非药物治疗对肌少症肥胖（SO）的影响。
方法
在PubMed、科学网、CINAHL、CENTRAL、SPORTDiscus、中国知网、万方和维普数据库中检索关于SO的随机对照试验（RCT）。采用随机效应模型对MD进行荟萃分析。
结果
对21项RCT的荟萃分析表明，运动可改善体脂率（MD：-1.67%，p < 0.01，I² = 35%）、握力（MD：2.2 kg，p = 0.03，I² = 61%）、步速（MD：0.08 m/s，p = 0.02，I² = 0%）、坐立试验重复次数（MD：2.22次，p < 0.01，I² = 0%）、定时起立行走试验时间（MD：-1.48 s，p < 0.01，I² = 61%）、上肢力量（MD：1.88 kg/kg，p < 0.01，I² = 0%）和下肢力量（MD：2.19 kg/kg，p < 0.01，I² = 0%）。营养干预可改善握力（MD：1.52 kg，p < 0.01，I² = 0%）。联合干预可改善体脂率（MD：-1.97%，p < 0.01，I² = 38%）、四肢骨骼肌质量（MD：0.4 kg，p < 0.01，I² = 6%）、握力（MD：1.83 kg，p < 0.01，I² = 38%）和步速（MD：0.04 m/s，p < 0.01，I² = 0%）。联合干预在降低体脂率方面比单纯营养干预更有效（MD：-0.8%，p = 0.05，I² = 0%）。
结论
运动和营养干预对SO的影响单独来看是有限的，尤其是在肌肉量方面，但两者结合可产生最佳效果。此外，物理治疗也显示出一些潜力。
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