Combination of deep learning reconstruction and quantification for dynamic contrast-enhanced (DCE) MRI.

Dynamic contrast-enhanced (DCE) MRI is an important imaging tool for evaluating tumor vascularity that can lead to improved characterization of tumor extent and heterogeneity, and for early assessment of treatment response. However, clinical adoption of quantitative DCE-MRI remains limited due to challenges in acquisition and quantification performance, and lack of automated tools. This study presents an end-to-end deep learning pipeline that exploits a novel deep reconstruction network called DCE-Movienet with a previously developed deep quantification network called DCE-Qnet for fast and quantitative DCE-MRI. DCE-Movienet offers rapid reconstruction of high spatiotemporal resolution 4D MRI data, reducing reconstruction time of the full acquisition to only 0.66 s, which is significantly shorter than compressed sensing's order of 10 min-long reconstructions, without affecting image quality. DCE-Qnet can then perform comprehensive quantification of perfusion parameter maps (K, v, v), and other parameters affecting quantification (T1, B1, and BAT) from a single contrast-enhanced acquisition. The end-to-end deep learning pipeline was implemented to process data acquired with a golden-angle stack-of-stars k-space trajectory and validated on healthy volunteers and a cervical cancer patient against a compressed sensing reconstruction. The end-to-end deep learning DCE-MRI technique addresses key limitations in DCE-MRI in terms of speed and quantification robustness, which is expected to improve the performance of DCE-MRI in a clinical setting.