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血管活性肠肽对离体人逼尿肌条自发收缩活动的抑制作用

Inhibition of spontaneous contractile activity in isolated human detrusor muscle strips by vasoactive intestinal polypeptide.

作者信息

Kinder R B, Mundy A R

出版信息

Br J Urol. 1985 Feb;57(1):20-3. doi: 10.1111/j.1464-410x.1985.tb08976.x.

DOI:10.1111/j.1464-410x.1985.tb08976.x
PMID:3971101
Abstract

In a study of 75 isolated human detrusor muscle strips, spontaneous contractions and an associated sustained rise in basal tension were observed in 43 (57%). Vasoactive intestinal polypeptide (VIP) caused significant reductions in the frequency and amplitude of spontaneous contractions and a fall in basal tension. The results suggest that VIP may have a role as an inhibitor of spontaneous activity in the human detrusor.

摘要

在一项对75条离体人逼尿肌条的研究中,在43条(57%)中观察到了自发收缩以及基础张力的相关持续升高。血管活性肠肽(VIP)可显著降低自发收缩的频率和幅度,并使基础张力下降。结果表明,VIP可能作为人逼尿肌自发活动的抑制剂发挥作用。

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