Zhou Lipeng, Cai Xinyu, Wang Ying, Yang Jianbo, Wang Yadan, Deng Jialing, Ye Danni, Zhang Lanzhen, Liu Yue, Ma Shuangcheng
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China.
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Nat Prod Rep. 2025 Feb 19;42(2):359-405. doi: 10.1039/d4np00033a.
Covering: 2009 up to the end of 2023Stilbenes, an emblematic group of polyphenols, have attracted the attention of numerous researchers owing to their intriguing polycyclic architectures and diverse bioactivities. In this updated review, natural stilbenes were analysed, especially oligomeric stilbenes, which are an emblematic group of polyphenols that harbor intriguing polycyclic architectures and diverse bioactivities compared with those previously anticipated. Oligomeric stilbenes with unique skeletons comprise a large majority of natural stilbenes owing to their structural changes and different substitutions on the phenyl rings. These compounds can be promising sources of lead compounds for studying new drugs and medicines. In addition, the exploration of unusual structures of oligomeric stilbenes such as polyflavanostilbenes A and B, analysing their absolute stereochemistry, and improving their yield using synthetic biology methods have recently gained interest. This review provides a systematic overview of 409 new stilbenes, which were isolated and identified over time from January 2009 to December 2023, focusing on the classification and biomimetic syntheses of oligomeric stilbenes, in addition to presenting meaningful insights into their structural diversity and biological activities, which will inspire further investigations of biological activities, structure-activity relationships, and screening of drug candidates.
2009年至2023年底
芪类化合物是一类具有代表性的多酚类化合物，因其引人入胜的多环结构和多样的生物活性而吸引了众多研究人员的关注。在这篇更新的综述中，对天然芪类化合物进行了分析，特别是低聚芪类化合物，它们是一类具有代表性的多酚类化合物，与之前预期的相比，具有引人入胜的多环结构和多样的生物活性。具有独特骨架的低聚芪类化合物由于其结构变化和苯环上不同的取代基，在天然芪类化合物中占了很大比例。这些化合物有望成为研究新药和药物的先导化合物来源。此外，对低聚芪类化合物如聚黄酮芪A和B的异常结构的探索、对其绝对立体化学的分析以及使用合成生物学方法提高其产量最近受到了关注。这篇综述对2009年1月至2023年12月期间随时间分离和鉴定的409种新芪类化合物进行了系统概述，重点关注低聚芪类化合物的分类和仿生合成，此外还对其结构多样性和生物活性提出了有意义的见解，这将激发对生物活性、构效关系和候选药物筛选的进一步研究。
