Department of Psychology, University of Toronto, Toronto, Ontario, Canada; Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.
Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
Neurobiol Aging. 2022 Sep;117:97-106. doi: 10.1016/j.neurobiolaging.2022.05.003. Epub 2022 May 13.
The present study explored whether early midlife bilateral salpingo-oophorectomy (BSO), a female-specific risk factor for dementia, is associated with reduced medial temporal lobe structure and function. Younger middle-aged women with the BRCA1/2 mutation and a BSO prior to spontaneous menopause (SM) were recruited. We determined the performance of women with BSO not taking estradiol-based hormone therapy (n = 18) on a task measuring object and scene recognition and quantified medial temporal lobe subregion volumes using manually segmented high-resolution T2-weighted MRI scans. Comparisons were made to those with BSO taking estradiol-based hormone therapy (n = 20), age-matched premenopausal controls (n = 28), and older women in SM not taking hormone therapy matched for duration of hormone deprivation (n = 17). Reduced hippocampal integrity specific to the BSO group not taking hormone therapy was observed, reflected by significantly smaller dentate gyrus/CA2/CA3 volumes and lower scene recognition memory performance. These findings show that hippocampal subfield volume may be useful for identifying early midlife changes in women at elevated risk for dementia.
本研究探讨了早中年双侧输卵管卵巢切除术（BSO）——一种女性特有的痴呆风险因素——是否与内侧颞叶结构和功能的减少有关。本研究招募了携带 BRCA1/2 突变且在自然绝经（SM）前接受 BSO 的年轻中年女性。我们评估了未接受雌二醇类激素治疗（n=18）的 BSO 女性在一项测量物体和场景识别的任务中的表现，并使用手动分割的高分辨率 T2 加权 MRI 扫描来量化内侧颞叶亚区体积。将其与接受雌二醇类激素治疗的 BSO 女性（n=20）、年龄匹配的绝经前对照组（n=28）和接受激素剥夺时间匹配的 SM 中未接受激素治疗的老年女性（n=17）进行比较。我们观察到未接受激素治疗的 BSO 组存在特定于海马体的完整性受损，表现为齿状回/CA2/CA3 体积明显减小和场景识别记忆表现降低。这些发现表明，海马体亚区体积可能有助于识别痴呆风险较高的女性早中年的变化。
