Mohd Ghazali Nur Ain Shafiyah, Wan Hitam Wan-Hazabbah, Maffar Nur Hafizah
Department of Ophthalmology and Visual Sciences, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MYS.
Cureus. 2024 Nov 20;16(11):e74066. doi: 10.7759/cureus.74066. eCollection 2024 Nov.
Sinonasal cancers are rare and aggressive head and neck malignancies. Sinonasal squamous cell carcinoma (SNSCC) typically affects males and individuals over the age of 55. Here, we present an unusual case of a young female diagnosed with SNSCC. She presented with painful right eye proptosis, rapid progressive vision loss in both eyes, and a history of intermittent epistaxis. MRI revealed an aggressive sinonasal mass with intra-orbital and intracranial extension, and a biopsy confirmed sinonasal non-keratinizing squamous cell carcinoma. Despite initial systemic chemotherapy, the patient discontinued treatment and, unfortunately, succumbed to the disease. This case highlights the aggressive nature and management challenges of advanced SNSCC, emphasizing the critical importance of early diagnosis and timely intervention to improve outcomes.
鼻窦癌是罕见的侵袭性头颈部恶性肿瘤。鼻窦鳞状细胞癌（SNSCC）通常影响男性和55岁以上的人群。在此，我们报告一例年轻女性被诊断为SNSCC的不寻常病例。她表现为右眼疼痛性眼球突出、双眼快速进行性视力丧失，并有间歇性鼻出血病史。MRI显示鼻窦有侵袭性肿块，累及眶内和颅内，活检证实为鼻窦非角化鳞状细胞癌。尽管最初进行了全身化疗，但患者停止了治疗，不幸的是，最终死于该疾病。该病例突出了晚期SNSCC的侵袭性本质和管理挑战，强调了早期诊断和及时干预以改善预后的至关重要性。
