Mandel Tiina, Iulietto Maria Francesca, Reinik Mari, Condoleo Roberto
National Centre for Laboratory Research and Risk Assessment (LABRIS) Tartu Estonia.
Istituto Zooprofilattico Sperimentale del Lazio e della Toscana (IZSLT) Rome Italy.
EFSA J. 2024 Dec 20;22(Suppl 1):e221117. doi: 10.2903/j.efsa.2024.e221117. eCollection 2024 Dec.
is one of the most reported causes of bacterial gastroenteritis worldwide. Birds are the predominant reservoirs for thermotolerant , therefore consumption of contaminated and undercooked poultry products represents one of the major transmission routes for campylobacteriosis. In addition to foodborne diseases, another relevant public challenge is the silent pandemic of antimicrobial resistance (AMR), impacting also the food chain. The occurrence of antimicrobial-resistant in broiler meat poses a significant threat to public health. In this context, quantitative microbiological risk assessment (QMRA) might support policy-makers in addressing these challenges. Hence, this project aimed to describe the current status of knowledge on occurrence of AMR at a global scale, with focus in estimating the prevalence of fluoroquinolone-resistant isolated from broiler meat at retail level. Following the drafting of a dedicated protocol, a systematic literature review and meta-analysis were conducted. Based on the extracted data, after the determination of the proportion of AMR isolates, the proportions were compared by species, geographical regions, processing step and sampling matrices. Meta-analysis allowed the estimation of the pooled prevalences of resistant isolates by regions and species, combining the findings from different independent studies in a comparable way. In terms of future perspectives, the outcome of this project will support future risk assessment and provide valuable inputs for estimating consumer exposure to AMR via broiler meat consumption. In conclusion, this report will provide a general overview of activities, preliminary results and research performed during the EU-FORA fellowship programme (2023/2024).
是全球报告最多的细菌性肠胃炎病因之一。鸟类是耐热菌的主要宿主，因此食用受污染和未煮熟的家禽产品是弯曲杆菌病的主要传播途径之一。除了食源性疾病，另一个相关的公共挑战是抗菌药物耐药性（AMR）的无声大流行，这也影响到了食物链。肉鸡中出现抗菌药物耐药菌对公众健康构成了重大威胁。在这种背景下，定量微生物风险评估（QMRA）可能会支持政策制定者应对这些挑战。因此，本项目旨在描述全球范围内抗菌药物耐药菌出现情况的现有知识状态，重点是估计零售层面从肉鸡中分离出的耐氟喹诺酮菌的流行率。在起草了专门的方案后，进行了系统的文献综述和荟萃分析。根据提取的数据，在确定抗菌药物耐药菌分离株的比例后，按菌种、地理区域、加工步骤和采样基质对这些比例进行了比较。荟萃分析允许以可比的方式结合不同独立研究的结果，按区域和菌种估计耐药菌分离株的合并流行率。就未来展望而言，本项目的结果将支持未来的风险评估，并为估计消费者通过食用肉鸡接触抗菌药物耐药菌提供有价值的投入。总之，本报告将概述欧盟 - FORA奖学金计划（2023/2024）期间开展的活动、初步结果和研究情况。
