Woodruff Gavin C, Moser Kimberly A
School of Biological Sciences, University of Oklahoma, Norman, Oklahoma, United States.
MicroPubl Biol. 2024 Dec 5;2024. doi: 10.17912/micropub.biology.001235. eCollection 2024.
The evolution of developmental rates may drive morphological change. develops nearly twice as slowly as . encodes a hydroxylase required for synthesizing ubiquinone, and mutant slow growth phenotypes can be rescued by supplying animals with a ubiquinone precursor analogue, 2,4-dihydroxybenzoate. RNA-seq data showing low expression raised the possibility that grows slowly because of reduced ubiquinone biosynthesis. did not reveal a clear reduction in the age of maturation when reared on 2,4-dihydroxybenzoate. Further scrutiny of RNA-seq results revealed multiple ubiquinone metabolism genes have low expression in . Divergent expression alone may not be a major driver of the evolution of slow development in this species.
发育速率的演变可能推动形态变化。[某物种A]的发育速度几乎是[某物种B]的两倍慢。[物种A]编码一种合成泛醌所需的羟化酶，并且通过向动物提供泛醌前体类似物2,4 - 二羟基苯甲酸，可以挽救[物种A]突变体的生长缓慢表型。RNA测序数据显示[物种A]的[相关基因]表达量低，这增加了[物种A]因泛醌生物合成减少而生长缓慢的可能性。在2,4 - 二羟基苯甲酸上饲养时，[物种A]并未显示出成熟年龄明显降低。对RNA测序结果的进一步审查发现，多个泛醌代谢基因在[物种A]中表达量低。仅[物种A]中[相关基因]表达的差异可能不是该物种发育缓慢进化的主要驱动因素。
