Lažetić Vladimir, Fay David S
Department of Molecular Biology, College of Agriculture and Natural Resources, University of Wyoming, Laramie, WY, USA.
Worm. 2017 May 17;6(1):e1330246. doi: 10.1080/21624054.2017.1330246. eCollection 2017.
Molting is an essential developmental process for the majority of animal species on Earth. During the molting process, which is a specialized form of extracellular matrix (ECM) remodeling, the old apical ECM, or cuticle, is replaced with a new one. Many of the genes and pathways identified as important for molting in nematodes are highly conserved in vertebrates and include regulators and components of vesicular trafficking, steroid-hormone signaling, developmental timers, and hedgehog-like signaling. In this review, we discuss what is known about molting, with a focus on studies in . We also describe the key structural elements of the cuticle that must be released, newly synthesized, or remodeled for proper molting to occur.
蜕皮是地球上大多数动物物种必不可少的发育过程。在蜕皮过程中，这是一种细胞外基质（ECM）重塑的特殊形式，旧的顶端ECM（即角质层）会被新的所取代。许多被确定对线虫蜕皮很重要的基因和信号通路在脊椎动物中高度保守，包括囊泡运输、类固醇激素信号传导、发育定时器和刺猬样信号传导的调节因子和组成部分。在这篇综述中，我们讨论了关于蜕皮的已知信息，重点是在……方面的研究。我们还描述了角质层的关键结构元素，为了使蜕皮正常发生，这些元素必须被释放、重新合成或重塑。
