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The Role of Awe and Other Psychological Factors in Ketamine's Mechanism of Antidepressant Action.

作者信息

Ansari Mina, Sanacora Gerard

机构信息

Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut.

出版信息

Biol Psychiatry Glob Open Sci. 2024 Sep 16;4(5):100353. doi: 10.1016/j.bpsgos.2024.100353. eCollection 2024 Sep.

DOI:10.1016/j.bpsgos.2024.100353
PMID:39713125
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11662274/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2edc/11662274/8e10d471bfd5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2edc/11662274/8e10d471bfd5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2edc/11662274/8e10d471bfd5/gr1.jpg

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本文引用的文献

1
Experiences of Awe Mediate Ketamine's Antidepressant Effects: Findings From a Randomized Controlled Trial in Treatment-Resistant Depression.敬畏体验介导氯胺酮的抗抑郁作用：难治性抑郁症随机对照试验的结果
Biol Psychiatry Glob Open Sci. 2024 Apr 6;4(4):100316. doi: 10.1016/j.bpsgos.2024.100316. eCollection 2024 Jul.
2
Randomized trial of ketamine masked by surgical anesthesia in patients with depression.手术麻醉掩盖下氯胺酮治疗抑郁症患者的随机试验。
Nat Ment Health. 2023 Nov;1(11):876-886. doi: 10.1038/s44220-023-00140-x. Epub 2023 Oct 19.
3
A Novel, Brief, Fully Automated Intervention to Extend the Antidepressant Effect of a Single Ketamine Infusion: A Randomized Clinical Trial.
一种新的、简短的、完全自动化的干预措施，可以延长单次氯胺酮输注的抗抑郁效果：一项随机临床试验。
Am J Psychiatry. 2022 Dec 1;179(12):959-968. doi: 10.1176/appi.ajp.20220216. Epub 2022 Sep 21.
4
Response to acute monotherapy for major depressive disorder in randomized, placebo controlled trials submitted to the US Food and Drug Administration: individual participant data analysis.美国食品和药物管理局提交的随机、安慰剂对照试验中治疗重度抑郁症急性单药治疗的反应：个体参与者数据分析。
BMJ. 2022 Aug 2;378:e067606. doi: 10.1136/bmj-2021-067606.
5
Placebo response and effect in randomized clinical trials: meta-research with focus on contextual effects.随机临床试验中的安慰剂反应与效应：聚焦背景效应的元研究
Trials. 2021 Jul 26;22(1):493. doi: 10.1186/s13063-021-05454-8.
6
The neural correlates of the awe experience: Reduced default mode network activity during feelings of awe.敬畏体验的神经关联：敬畏感时默认模式网络活动减少。
Hum Brain Mapp. 2019 Aug 15;40(12):3561-3574. doi: 10.1002/hbm.24616. Epub 2019 May 7.
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Awe: a putative mechanism underlying the effects of classic psychedelic-assisted psychotherapy.敬畏：经典迷幻辅助心理疗法作用的潜在机制。
Int Rev Psychiatry. 2018 Aug;30(4):331-342. doi: 10.1080/09540261.2018.1474185. Epub 2018 Sep 27.
8
Default Mode Connectivity in Major Depressive Disorder Measured Up to 10 Days After Ketamine Administration.在氯胺酮给药后 10 天测量的重度抑郁症中的默认模式连接。
Biol Psychiatry. 2018 Oct 15;84(8):582-590. doi: 10.1016/j.biopsych.2018.01.027. Epub 2018 Feb 15.
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A theoretical analysis showed that blinding cannot eliminate potential for bias associated with beliefs about allocation in randomized clinical trials.一项理论分析表明，在随机临床试验中，盲法无法消除与分配相关信念所带来的潜在偏倚可能性。
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