Genetics Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
J Cell Physiol. 2020 Jul;235(7-8):5501-5510. doi: 10.1002/jcp.29558. Epub 2020 Jan 27.
Circular RNAs (circRNAs) were recently discovered as a looped subset of competing endogenous RNAs, with an ability to regulate gene expression by microRNA sponging. There are several studies on their potential roles in cancer development, such as colorectal cancer and basal cell carcinoma. However, there is still a significant gap in the knowledge about circRNA functions in breast cancer (BC) progression. The current study systematically reviewed circRNA biogenesis and their potential roles as a novel biomarker in BC on published studies of the MEDLINE®/PubMed, Cochrane®, and Scopus® databases. The obtained results showed a general dysregulation of circRNAs expression in BC cells with a cell-type and stage-specific manner. The potential connection between circRNAs and BC cell proliferation, apoptosis, metastasis, and chemotherapy sensitivity and resistance were discussed.
环状 RNA（circRNAs）最近被发现是竞争性内源性 RNA 的一个环状亚群，具有通过 microRNA 海绵作用来调节基因表达的能力。有几项关于它们在癌症发展中的潜在作用的研究，如结直肠癌和基底细胞癌。然而，关于环状 RNA 在乳腺癌（BC）进展中的功能的知识仍然存在很大的差距。本研究系统地综述了环状 RNA 的生物发生及其作为 BC 新型生物标志物的潜在作用，检索了 MEDLINE®/PubMed、Cochrane®和 Scopus®数据库中发表的研究。研究结果表明，BC 细胞中的 circRNAs 表达普遍失调，且具有细胞类型和阶段特异性。讨论了 circRNAs 与 BC 细胞增殖、凋亡、转移以及化疗敏感性和耐药性之间的潜在联系。
