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INWORKS研究及广岛/长崎白血病研究结果。

INWORKS and Hiroshima/Nagasaki Leukaemia Results.

作者信息

Chaplin Ken Robert

机构信息

Canadian Nuclear Laboratories - Retired, Chalk River, ON, Canada.

出版信息

Dose Response. 2024 Dec 19;22(4):15593258241303476. doi: 10.1177/15593258241303476. eCollection 2024 Oct-Dec.

Abstract

The Hiroshima/Nagasaki (H/N) studies by the Radiation Effect Research Foundation have not shown increased leukaemia for acute doses below 200 milli-gray (mGy). By contrast the INWORKS study of leukaemia in workers stated: "This study provides strong evidence of positive associations between protracted low-dose radiation exposure and leukemia". The INWORKS study also claimed increased leukaemia, not including Chronic Lymphocytic Leukaemia, at cumulative occupational doses of less than 100 mGy. This is contrary to the expectation that the H/N studies would show more severe effects than the worker study because the doses were acute instead of chronic and because the H/N studies included children who had higher rates of radiation induced leukaemia than adults. This paper shows that the INWORKS leukaemia study is consistent with the H/N studies in showing no increase in leukaemia in the low-dose range. In addition, any increase in leukaemia is confined to Chronic Myeloid Leukaemia, possibly from high radiation dose-rates or chemicals.

摘要

辐射效应研究基金会开展的广岛/长崎(H/N)研究表明,急性剂量低于200毫戈瑞(mGy)时白血病发病率并未增加。相比之下,INWORKS关于工人白血病的研究称:“本研究提供了有力证据,证明长期低剂量辐射暴露与白血病之间存在正相关”。INWORKS研究还称,累积职业剂量低于100 mGy时,白血病发病率增加,慢性淋巴细胞白血病除外。这与预期相反,即H/N研究应比工人研究显示出更严重的影响,因为H/N研究中的剂量是急性的而非慢性的,且H/N研究中的儿童辐射诱发白血病的发生率高于成年人。本文表明,INWORKS白血病研究与H/N研究一致,即在低剂量范围内白血病发病率并未增加。此外,白血病发病率的任何增加都仅限于慢性髓性白血病,可能是由于高辐射剂量率或化学物质所致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9e2/11660241/6dd3b22b6005/10.1177_15593258241303476-fig1.jpg

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