Zhu Jieli, Zhao Liangyou, An Weihao, Miao Qingqing
School of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230026, China.
State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China.
Chem Soc Rev. 2025 Feb 3;54(3):1429-1452. doi: 10.1039/d4cs01060d.
Long-lasting afterglow luminescence imaging that detects photons slowly being released from chemical defects has emerged, eliminating the need for real-time photoexcitation and enabling autofluorescence-free imaging with high signal-to-background ratios (SBRs). Organic afterglow nano-systems are notable for their tunability and design versatility. However, challenges such as unsatisfactory afterglow intensity, short emission wavelengths, limited activatable strategies, and shallow tissue penetration depth hinder their widespread biomedical applications and clinical translation. Such contradiction between promising prospects and insufficient properties has spurred researchers' efforts to improve afterglow performance. In this review, we briefly outline the general composition and mechanisms of organic afterglow luminescence, with a focus on design strategies and an in-depth understanding of the structure-property relationship to advance afterglow luminescence imaging. Furthermore, pending issues and future perspectives are discussed.
能够检测从化学缺陷中缓慢释放的光子的长效余辉发光成像技术已经出现，它无需实时光激发，能够实现无自发荧光的高信背比（SBR）成像。有机余辉纳米系统因其可调性和设计多功能性而备受关注。然而，诸如余辉强度不理想、发射波长较短、可激活策略有限以及组织穿透深度较浅等挑战阻碍了它们在生物医学领域的广泛应用和临床转化。这种前景广阔与性能不足之间的矛盾促使研究人员努力提高余辉性能。在本综述中，我们简要概述了有机余辉发光的一般组成和机制，重点介绍了设计策略以及对结构-性能关系的深入理解，以推动余辉发光成像技术的发展。此外，还讨论了悬而未决的问题和未来展望。
