Yi Jun, You En-Ming, Hu Ren, Wu De-Yin, Liu Guo-Kun, Yang Zhi-Lin, Zhang Hua, Gu Yu, Wang Yao-Hui, Wang Xiang, Ma Hao, Yang Yang, Liu Jun-Yang, Fan Feng Ru, Zhan Chao, Tian Jing-Hua, Qiao Yu, Wang Hailong, Luo Si-Heng, Meng Zhao-Dong, Mao Bing-Wei, Li Jian-Feng, Ren Bin, Aizpurua Javier, Apkarian Vartkess Ara, Bartlett Philip N, Baumberg Jeremy, Bell Steven E J, Brolo Alexandre G, Brus Louis E, Choo Jaebum, Cui Li, Deckert Volker, Domke Katrin F, Dong Zhen-Chao, Duan Sai, Faulds Karen, Frontiera Renee, Halas Naomi, Haynes Christy, Itoh Tamitake, Kneipp Janina, Kneipp Katrin, Le Ru Eric C, Li Zhi-Peng, Ling Xing Yi, Lipkowski Jacek, Liz-Marzán Luis M, Nam Jwa-Min, Nie Shuming, Nordlander Peter, Ozaki Yukihiro, Panneerselvam Rajapandiyan, Popp Jürgen, Russell Andrea E, Schlücker Sebastian, Tian Yang, Tong Lianming, Xu Hongxing, Xu Yikai, Yang Liangbao, Yao Jianlin, Zhang Jin, Zhang Yang, Zhang Yao, Zhao Bing, Zenobi Renato, Schatz George C, Graham Duncan, Tian Zhong-Qun
State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, School of Electronic Science and Engineering, College of Environment and Ecology, State Key Laboratory of Marine Environmental Science, Department of Physics, iChEM, IKKEM, Xiamen University, Xiamen 361005, China.
School of Ocean Information Engineering, Fujian Provincial Key Laboratory of Oceanic Information Perception and Intelligent Processing, Jimei University, Xiamen 361021, China.
Chem Soc Rev. 2025 Feb 3;54(3):1453-1551. doi: 10.1039/d4cs00883a.
Surface-enhanced Raman spectroscopy (SERS) has evolved significantly over fifty years into a powerful analytical technique. This review aims to achieve five main goals. (1) Providing a comprehensive history of SERS's discovery, its experimental and theoretical foundations, its connections to advances in nanoscience and plasmonics, and highlighting collective contributions of key pioneers. (2) Classifying four pivotal phases from the view of innovative methodologies in the fifty-year progression: initial development (mid-1970s to mid-1980s), downturn (mid-1980s to mid-1990s), nano-driven transformation (mid-1990s to mid-2010s), and recent boom (mid-2010s onwards). (3) Illuminating the entire journey and framework of SERS and its family members such as tip-enhanced Raman spectroscopy (TERS) and shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) and highlighting the trajectory. (4) Emphasizing the importance of innovative methods to overcome developmental bottlenecks, thereby expanding the material, morphology, and molecule generalities to leverage SERS as a versatile technique for broad applications. (5) Extracting the invaluable spirit of groundbreaking discovery and perseverant innovations from the pioneers and trailblazers. These key inspirations include proactively embracing and leveraging emerging scientific technologies, fostering interdisciplinary cooperation to transform the impossible into reality, and persistently searching to break bottlenecks even during low-tide periods, as luck is what happens when preparation meets opportunity.
表面增强拉曼光谱（SERS）在过去五十多年里已发展成为一种强大的分析技术。本综述旨在实现五个主要目标。（1）全面回顾SERS的发现历程、其实验和理论基础、与纳米科学和等离子体学进展的联系，并突出关键先驱者的集体贡献。（2）从五十年来创新方法的角度对四个关键阶段进行分类：初始发展阶段（20世纪70年代中期至80年代中期）、低谷阶段（20世纪80年代中期至90年代中期）、纳米驱动转型阶段（20世纪90年代中期至2010年代中期）以及近期的繁荣阶段（2010年代中期至今）。（3）阐明SERS及其家族成员如针尖增强拉曼光谱（TERS）和壳层隔离纳米粒子增强拉曼光谱（SHINERS）的整个发展历程和框架，并突出其发展轨迹。（4）强调创新方法对于克服发展瓶颈的重要性，从而扩大材料、形态和分子的通用性，使SERS成为一种适用于广泛应用的通用技术。（5）从先驱者和开拓者身上汲取开创性发现和坚持不懈创新的宝贵精神。这些关键启示包括积极拥抱和利用新兴科学技术、促进跨学科合作将不可能变为现实，以及即使在低谷期也持续寻求突破瓶颈，因为机遇总是留给有准备的人。
