口腔扁平苔藓中唾液微小RNA-93和微小RNA-412-3p的致癌潜力：一项病例对照研究。

The oncogenic potential of salivary microRNA-93 and microRNA-412-3p in oral lichen planus: a case-control study.

作者信息

ELHefny Moataz M, Korien Inas A, Rashwan Weam Am, Shaker Olfat G

机构信息

Department of Oral Medicine, Oral Diagnosis and Periodontology, Faculty of Dentistry, Horus University, New Damietta, Egypt.

Department of Oral Medicine, Oral Diagnosis and Periodontology, Faculty of Dentistry, Cairo University, Cairo, Egypt.

出版信息

BDJ Open. 2024 Dec 23;10(1):98. doi: 10.1038/s41405-024-00278-5.

DOI:10.1038/s41405-024-00278-5

PMID:39715775

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11666714/

Abstract

BACKGROUND

Oral Lichen Planus is one of the most popular chronic mucocutaneous diseases. It is classified as potentially malignant lesions. Many microRNAs can be used as biological markers for the disease and for its malignant transformation. The aim of the study to measure the expression of microRNA-93 and microRNA-412-3p in Oral Lichen Planus patients, patients diagnosed as Oral Squamous Cell Carcinoma and healthy controls.

METHODOLOGY

A total of 60 patients were divided into 3 groups; each group contains 20 patients. Group I for Oral Lichen Planus patients, group II for healthy controls and group III for Oral Squamous cell carcinoma patients. All of these patients were chosen from those attending Kasr Al-Einy hospital, Cairo University. After full diagnosis and matching of our eligibility criteria, saliva sample was taken from each patient to measure the concentration of microRNA-93 and microRNA-412-3p.

RESULTS

Both microRNA-93 and miceoRNA-412-3p were upregulated in Oral Squamous cell carcinoma patients than Oral Lichen patients than controls and both of them had great sensitivity, specificity and diagnostic accuracy for both Oral Lichen Planus and Oral Squamous cell carcinoma.

CONCLUSION

MicroRNA-93 and micriRNA-412-3p can be used as diagnostic markers and for the oncogenic potential of Oral Lichen Planus.

摘要

背景

口腔扁平苔藓是最常见的慢性黏膜皮肤疾病之一。它被归类为潜在恶性病变。许多微小RNA可作为该疾病及其恶性转化的生物标志物。本研究旨在测量口腔扁平苔藓患者、被诊断为口腔鳞状细胞癌的患者以及健康对照者中微小RNA - 93和微小RNA - 412 - 3p的表达。

方法

总共60名患者被分为3组；每组包含20名患者。第一组为口腔扁平苔藓患者，第二组为健康对照者，第三组为口腔鳞状细胞癌患者。所有这些患者均选自开罗大学卡斯尔·艾因尼医院的就诊者。在根据我们的纳入标准进行全面诊断和匹配后，从每位患者采集唾液样本以测量微小RNA - 93和微小RNA - 412 - 3p的浓度。