Mansourian Arash, Shanbehzadeh Najmeh, Kia Seyed Javad, Moosavi Mahdieh-Sadat
Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences - Tehran, Iran.
Department of Oral Medicine, School of Dentistry, Hormozgan University of Medical Sciences - Bandar Abbas, Iran.
An Bras Dermatol. 2017 Mar-Apr;92(2):168-171. doi: 10.1590/abd1806-4841.20174964.
: Oral lichen planus is a potentially malignant disorder. One of the malignant transformation markers is cancer stem cells. One of the proposed marker for the detection of cancer stem cells's in head and neck cancer is aldehyde dehydrogenase. Recently it is shown that aldehyde dehydrogenase 1 expression in tissue samples is associated with oral lichen planus malignant transformation.
: This study evaluates salivary aldehyde dehydrogenase 1 in oral lichen planus.
: Thirty patients and 30 age and sex-matched healthy volunteers were recruited. Oral lichen planus was diagnosed based on the modified World Health Organization criteria. Subjects in the case group were divided into reticular and non-reticular forms. Unstimulated salivary samples were collected at 10-12 AM. Saliva concentrations of aldehyde dehydrogenase 1 were measured by ELISA.
: The differences between aldehyde dehydrogenase levels in the oral lichen planus group compared with the control group were not significant but aldehyde dehydrogenase in non-reticular oral lichen planus was significantly higher than that of the reticular form.
: This is a cross-sectional study, thus longitudinal studies in oral lichen planus may present similar or different results.
: The mechanism of malignant transformation in oral lichen planus is not defined. Previous analyses revealed that the aldehyde dehydrogenase 1 expression is significantly correlated with increased risk of transformation. This finding is consistent with our results because in the erosive and ulcerative forms of oral lichen planus, which have an increased risk of transformation, salivary aldehyde dehydrogenase 1 was overexpressed. A higher salivary aldehyde dehydrogenase level in non-reticular oral lichen planus can be a defensive mechanism against higher oxidative stress in these groups. Aldehyde dehydrogenase may be one of the malignant transformation markers in oral lichen planus. Further studies are needed for introducing aldehyde dehydrogenase as a prognostic indicator in certain lesions.
口腔扁平苔藓是一种潜在的恶性疾病。恶性转化标志物之一是癌症干细胞。用于检测头颈癌中癌症干细胞的一种标志物是醛脱氢酶。最近有研究表明，组织样本中醛脱氢酶1的表达与口腔扁平苔藓的恶性转化有关。
本研究评估口腔扁平苔藓患者唾液中的醛脱氢酶1。
招募30例患者和30名年龄及性别匹配的健康志愿者。根据修改后的世界卫生组织标准诊断口腔扁平苔藓。病例组受试者分为网状型和非网状型。上午10点至12点收集非刺激性唾液样本。采用酶联免疫吸附测定法测量唾液中醛脱氢酶1的浓度。
口腔扁平苔藓组与对照组的醛脱氢酶水平差异无统计学意义，但非网状型口腔扁平苔藓中的醛脱氢酶水平显著高于网状型。
本研究为横断面研究，因此口腔扁平苔藓的纵向研究可能会得出相似或不同的结果。
口腔扁平苔藓的恶性转化机制尚不明确。先前的分析表明，醛脱氢酶1的表达与转化风险增加显著相关。这一发现与我们的结果一致，因为在具有较高转化风险的糜烂型和溃疡型口腔扁平苔藓中，唾液醛脱氢酶1过表达。非网状型口腔扁平苔藓中较高的唾液醛脱氢酶水平可能是这些患者对抗更高氧化应激的一种防御机制。醛脱氢酶可能是口腔扁平苔藓的恶性转化标志物之一。需要进一步研究以将醛脱氢酶作为某些病变的预后指标。
