Zhao Jian-Feng, Yang Chen, Zhou Jie, Zhang Hai-Yan, Geng Yu
Department of Ophthalmology, The First Affiliated Hospital of Kunming Medical University, Kunming 650031, China.
Department of Ophthalmology, The First Affiliated Hospital of Kunming Medical University, Kunming 650031, China.
Photodiagnosis Photodyn Ther. 2025 Feb;51:104453. doi: 10.1016/j.pdpdt.2024.104453. Epub 2024 Dec 21.
To assess the variability and correlation of ocular biometric parameters in eyes with cataracts and examine their association with age and gender.
A retrospective analysis was performed on biometric data from 7,458 eyes without retinal pathologies, using an optical biometer equipped with low-coherence reflectometry technology. Pearson's correlation coefficients (r) were used to evaluate the relationships between age, gender, and various ocular parameters, including axial length (AL), anterior chamber depth (ACD), lens thickness (LT), central corneal thickness (CCT), corneal refractive power (Km), and white-to-white (WTW) measurement.
The mean AL was 23.82 ± 1.83 mm (SD). Among the study cohort, 8.0 % (593 eyes) were categorized as having short AL (AL ≤ 22 mm), 60.5 % (4,520 eyes) as having normal AL (22 mm < AL ≤ 24 mm), 21.2 % (1,579 eyes) as having long AL (24 mm < AL ≤ 26 mm), and 10.3 % (766 eyes) as having a AL (> 26 mm). The mean age of the cohort was 64.18 ± 14.95 years (range: 18 - 98 years), with males averaging 56.53 ± 13.88 years and females averaging 72.19 ± 11.41 years. Mean values for ACD, LT, Km, CCT, WTW, and angle kappa were found to vary with both age and gender. Males demonstrated significantly longer AL, deeper ACD, thicker LT, larger WTW, and lower Km compared to females (P < 0.05). Although males exhibited a greater anterior segment length (ASL), this difference did not reach statistical significance (P > 0.05). No significant correlation was found between ACD and AL in the short and long AL groups, while a positive correlation was observed in the normal and long AL groups. Additionally, LT demonstrated a negative correlation with AL in the normal AL group but a positive correlation in the long AL group.
Cataracts develop at a greater age in female patients than in males. Ocular biometric parameters, including ACD, LT, CCT, Km, and (WTW) measurement, are influenced by age and gender. Lens thickness is the primary factor affecting ACD, though CCT, Km, and WTW also play significant roles. Furthermore, a negative correlation between AL and LT was identified, with variations depending on AL classification.
评估白内障患者眼部生物测量参数的变异性和相关性，并研究它们与年龄和性别的关系。
对7458只无视网膜病变眼睛的生物测量数据进行回顾性分析，使用配备低相干反射测量技术的光学生物测量仪。采用Pearson相关系数（r）评估年龄、性别与各种眼部参数之间的关系，这些参数包括眼轴长度（AL）、前房深度（ACD）、晶状体厚度（LT）、中央角膜厚度（CCT）、角膜屈光力（Km）和白对白（WTW）测量值。
平均眼轴长度为23.82±1.83mm（标准差）。在研究队列中，8.0%（593只眼）被归类为短眼轴（AL≤22mm），60.5%（4520只眼）为正常眼轴（22mm＜AL≤24mm），21.2%（1579只眼）为长眼轴（24mm＜AL≤26mm），10.3%（766只眼）为超长眼轴（AL＞26mm）。队列的平均年龄为64.18±14.95岁（范围：18 - 98岁），男性平均年龄为56.53±13.88岁，女性平均年龄为72.19±11.41岁。发现前房深度、晶状体厚度、角膜屈光力、中央角膜厚度、白对白测量值和kappa角的平均值随年龄和性别而变化。与女性相比，男性的眼轴明显更长，前房更深，晶状体更厚，白对白更大，角膜屈光力更低（P＜0.05）。尽管男性的前段长度更长，但这种差异未达到统计学意义（P＞0.05）。在短眼轴组和长眼轴组中，前房深度与眼轴长度之间未发现显著相关性，而在正常眼轴组和长眼轴组中观察到正相关。此外，在正常眼轴组中晶状体厚度与眼轴长度呈负相关，而在长眼轴组中呈正相关。
女性患者白内障发病年龄比男性大。包括前房深度、晶状体厚度、中央角膜厚度、角膜屈光力和白对白测量值在内的眼部生物测量参数受年龄和性别的影响。晶状体厚度是影响前房深度的主要因素，不过中央角膜厚度、角膜屈光力和白对白也起重要作用。此外，确定了眼轴长度与晶状体厚度之间存在负相关，且因眼轴分类不同而有所变化。
