Feng Xi, Wang Yong, Liang Jianheng, Xu Yali, Ortega-Usobiaga Julio, Cao Danmin
Aier School of Ophthalmology, Central South University, Changsha, Hunan Province, China.
Aier Eye Hospital of Wuhan University, Aier Eye Hospital Group, Wuhan, Hubei Province, China.
J Ophthalmol. 2021 Dec 30;2021:4717996. doi: 10.1155/2021/4717996. eCollection 2021.
This study aimed to analyze the distribution of lens thickness (LT) and its associations in age-related cataract patients based on swept-source optical coherence tomography (SS-OCT).
This cross-sectional study included 59,726 Chinese age-related cataract patients. Only right-eye data were included in the study. Repeated measures of ocular parameters were performed using an IOL Master 700 device. The distributions of ocular biometric data including anterior chamber depth (ACD), LT, axial length (AL), central corneal thickness (CCT), white-to-white (WTW), and mean keratometry (MK) and their associations with age were assessed. The anterior segment (AS) was measured as the sum of CCT, ACD, and LT, while the vitreous chamber depth (VCD) was calculated as the difference between AL and AS. The values of LT : AL, AS : AL, and VCD : AL in different AL groups and their changes are the main outcome measures used to observe the proportion of the anterior and posterior segments of the eye.
Biometric data were available for 59,726 individuals. The mean age was 68.81 years (range = 40-100); 40.62% were male and 59.38% were female. Mean anterior chamber depth (ACD) was 3.02 ± 0.44 mm, mean LT was 4.51 ± 0.44 mm, mean axial length (AL) was 23.89 ± 1.92 mm, mean central corneal thickness (CCT) was 0.53 ± 0.03 mm, mean white-to-white (WTW) was 11.64 ± 0.44 mm, and mean keratometry (MK) was 44.27 ± 1.65 diopter. Female patients had shorter AL, shallower ACD, smaller CCT and WTW, decreased LT, and steeper corneas ( < 0.005). ACD revealed the strongest negative correlation ( ≤ 0.001, = -0.682) with LT. Age ( ≤ 0.001, = 0.348) showed a moderate positive correlation, whereas MK ( ＜ 0.05, = 0.011), CCT ( ≤ 0.001, = 0.041) had a weak positive correlation and WTW ( ≤ 0.001, = -0.034) had a weak negative correlation with LT. A nonlinear correlation was found between LT and AL. LT increased with age in both males and females. LT changed variably in eyes with AL less than 27 mm, LT decreased as AL increased, then LT gradually increased as AL increased in extremely long and extra-long eyes ( ≤ 0.001). LT : AL and AS : AL decreased as AL increased, VCD : AL gradually increased as AL increased in highly myopic eyes, and VCD : AL increased by about 0.01 for every 1 mm increase in AL.
Among Chinese age-related cataract patients, we found LT to have the strongest relation with ACD. The lens was thicker in elderly patients and women. The correlation between LT and AL is not a simple negative correlation; with the increase of age, LT decreases first and then increases. The proportion of VCD is constantly rising with the elongation of AL.
本研究旨在基于扫频光学相干断层扫描（SS-OCT）分析年龄相关性白内障患者的晶状体厚度（LT）分布及其相关性。
本横断面研究纳入了59726例中国年龄相关性白内障患者。研究仅纳入右眼数据。使用IOL Master 700设备对眼部参数进行重复测量。评估包括前房深度（ACD）、LT、眼轴长度（AL）、中央角膜厚度（CCT）、白到白（WTW）和平均角膜曲率（MK）在内的眼部生物测量数据的分布及其与年龄的相关性。前段（AS）测量为CCT、ACD和LT之和，而玻璃体腔深度（VCD）计算为AL与AS之差。不同AL组中LT∶AL、AS∶AL和VCD∶AL的值及其变化是用于观察眼前后段比例的主要观察指标。
59726例个体有生物测量数据。平均年龄为68.81岁（范围=40-100岁）；男性占40.62%，女性占59.38%。平均前房深度（ACD）为3.02±0.44mm，平均LT为4.51±0.44mm，平均眼轴长度（AL）为23.89±1.92mm，平均中央角膜厚度（CCT）为0.53±0.03mm，平均白到白（WTW）为11.64±0.44mm，平均角膜曲率（MK）为44.27±1.65屈光度。女性患者的AL较短，ACD较浅，CCT和WTW较小，LT降低，角膜较陡（P<0.005）。ACD与LT呈最强的负相关（P≤0.001，r=-0.682）。年龄（P≤0.001，r=0.348）呈中度正相关，而MK（P<0.05，r=0.011）、CCT（P≤0.001，r=0.041）与LT呈弱正相关，WTW（P≤0.001，r=-0.034）与LT呈弱负相关。LT与AL之间存在非线性相关性。LT在男性和女性中均随年龄增加。在AL小于27mm的眼中LT变化多样，随着AL增加LT降低，然后在极长眼和超长眼中随着AL增加LT逐渐增加（P≤0.001）。随着AL增加，LT∶AL和AS∶AL降低，在高度近视眼中VCD∶AL随着AL增加逐渐增加，并且AL每增加1mm，VCD∶AL增加约0.01。
在中国年龄相关性白内障患者中，我们发现LT与ACD关系最强。老年患者和女性的晶状体较厚。LT与AL之间的相关性不是简单的负相关；随着年龄增加，LT先降低后增加。随着AL延长，VCD的比例不断上升。
