Weingart W A, Sorkness C A, Earhart R H
Clin Pharm. 1985 Jan-Feb;4(1):53-8.
A scheduled regimen of oral narcotic analgesics was compared with a regimen of oral narcotic analgesics plus ibuprofen for analgesic efficacy in patients with cancer. Ten patients with metastatic cancer were randomly assigned to receive either ibuprofen 400 mg or a look-alike placebo four times daily in addition to each patient's existing regimen of scheduled oral narcotics. A two-period changeover study design was used. The 24-hour narcotic intake equated to injectable morphine was computed for each patient at baseline and during the nine study days. A visual analogue scale was used to evaluate pain relief, nausea, mood depression, daytime drowsiness and nighttime sleeplessness. The analgesic efficacy of the narcotic-ibuprofen combination was significantly greater than the analgesic efficacy of the narcotic-placebo combination. Eight patients demonstrated a positive treatment effect with added ibuprofen; the overall improvement in analgesia averaged 39.1% in these patients. There was no significant increase from baseline in the incidence of nausea, mood depression, daytime drowsiness or nighttime sleeplessness. At the doses used in this study, a treatment regimen of oral narcotic analgesics plus ibuprofen was more effective than oral narcotics alone in relieving pain associated with cancer.
将口服麻醉性镇痛药的常规方案与口服麻醉性镇痛药加布洛芬的方案进行比较，以评估其对癌症患者的镇痛效果。10例转移性癌症患者被随机分配，除了他们现有的口服麻醉性镇痛药常规方案外，每天4次服用400毫克布洛芬或外观相似的安慰剂。采用两阶段交叉研究设计。在基线期和9个研究日期间，计算每名患者相当于注射用吗啡的24小时麻醉药摄入量。使用视觉模拟量表评估疼痛缓解、恶心、情绪低落、日间嗜睡和夜间失眠情况。麻醉药-布洛芬组合的镇痛效果明显优于麻醉药-安慰剂组合。8例患者在加用布洛芬后显示出积极的治疗效果；这些患者的镇痛总体改善平均为39.1%。恶心、情绪低落、日间嗜睡或夜间失眠的发生率与基线相比没有显著增加。在本研究使用的剂量下，口服麻醉性镇痛药加布洛芬的治疗方案在缓解癌症相关疼痛方面比单纯口服麻醉药更有效。
