Jash Eshna, Csankovszki Györgyi
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
DNA (Basel). 2024 Mar;4(1):64-83. doi: 10.3390/dna4010004. Epub 2024 Feb 22.
Embryogenesis is characterized by dynamic chromatin remodeling and broad changes in chromosome architecture. These changes in chromatin organization are accompanied by transcriptional changes, which are crucial for the proper development of the embryo. Several independent mechanisms regulate this process of chromatin reorganization, including segregation of chromatin into heterochromatin and euchromatin, deposition of active and repressive histone modifications, and the formation of 3D chromatin domains such as TADs and LADs. These changes in chromatin structure are directly linked to developmental milestones such as the loss of developmental plasticity and acquisition of terminally differentiated cell identities. In this review we summarize these processes that underlie this chromatin reorganization and their impact on embryogenesis in the nematode .
胚胎发生的特点是动态的染色质重塑和染色体结构的广泛变化。染色质组织的这些变化伴随着转录变化，这对胚胎的正常发育至关重要。几种独立的机制调节着这种染色质重组过程，包括将染色质分离为异染色质和常染色质、活性和抑制性组蛋白修饰的沉积，以及三维染色质结构域（如拓扑相关结构域和核仁相关结构域）的形成。染色质结构的这些变化与发育里程碑直接相关，如发育可塑性的丧失和终末分化细胞身份的获得。在这篇综述中，我们总结了这种染色质重组背后的这些过程及其对线虫胚胎发生的影响。
