Teng Teng, Kong Chun-Yan, Huang Rong, Ma Zhen-Guo, Hu Can, Zhang Xin, Hu Min, Tang Qi-Zhu
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, China.
Front Cardiovasc Med. 2022 Nov 4;9:1046377. doi: 10.3389/fcvm.2022.1046377. eCollection 2022.
Ferroptosis is a unique cell death depended on iron metabolism disorder which is different from previous apoptosis-regulated cell death. Early studies have proposed that ferroptosis is closely associated with multiple cardiovascular diseases (CVDs). However, the relationship of ferroptosis and CVDs has not been summarized by using bibliometric analysis. We intended to illustrate the development of ferroptosis in CVDs over the past years and provide relevant valuable information.
The authoritative database of Web of Science Core Collection was collected for retrieving ferroptosis studies in CVDs. In this work, statistical and visualization analysis were conducted using VOSviewer and Citespace.
A total of 263 studies were included in the final study. From the perspective of the overall literature, the study maintains an increased trend year by year and most manuscripts belonged to original article. China was the most productive country with the utmost scientific research output, as well as the institutions and authors, followed by Germany and the United States of America (USA). Jun Peng from China contributes to the most publications. Collaborative efforts between institutes and authors were limited and there was little widespread cooperation. In addition, burst keywords analysis discovered that ischemia-reperfusion (I/R) injury, heart failure (HF), and atherosclerosis were the top three research directions of ferroptosis in CVDs. The burst investigation and timeline views also indicated that endothelial injury and gut microbiota may also serve as new research topics in the future.
This study provided comprehensive and specific information about the most influential articles on ferroptosis in CVDs. The relationship between ferroptosis and CVDs had attracted the scholar's concerns especially in China. Cooperations and communications between countries and institutions should be emphasized and future directions can be concentrated on endothelial disorder and gut microbiota.
铁死亡是一种独特的细胞死亡方式，依赖于铁代谢紊乱，不同于以往凋亡调节的细胞死亡。早期研究表明，铁死亡与多种心血管疾病（CVD）密切相关。然而，尚未通过文献计量分析总结铁死亡与心血管疾病之间的关系。我们旨在阐述过去几年铁死亡在心血管疾病中的发展情况，并提供相关有价值的信息。
收集Web of Science核心合集这一权威数据库，以检索心血管疾病中铁死亡的研究。在本研究中，使用VOSviewer和Citespace进行统计和可视化分析。
最终纳入263项研究。从整体文献来看，该研究呈逐年增加趋势，且大多数稿件属于原创文章。中国是产出最多的国家，在科研产出、机构和作者方面均居首位，其次是德国和美国。中国的彭军发表的文章最多。机构和作者之间的合作有限，缺乏广泛的合作。此外，突发关键词分析发现，缺血再灌注（I/R）损伤、心力衰竭（HF）和动脉粥样硬化是心血管疾病中铁死亡的前三大研究方向。突发调查和时间线视图还表明，内皮损伤和肠道微生物群可能也是未来的新研究课题。
本研究提供了有关心血管疾病中铁死亡最具影响力文章的全面而具体的信息。铁死亡与心血管疾病之间的关系已引起学者们的关注，尤其是在中国。应强调国家和机构之间的合作与交流，未来的方向可集中在内皮功能障碍和肠道微生物群方面。
