Hogenelst Koen, Krone Tanja, Eveleens Maarse Boukje, Warnke Ines, Snabel Jessica, van den Broek Tim J, Schuren Frank, Moerland Matthijs, Hoevenaars Femke P M
Department of Human Performance, The Netherlands Organisation for Applied Scientific Research (TNO), Soesterberg, the Netherlands.
Department of Risk Analysis for Products in Development, The Netherlands Organisation for Applied Scientific Research (TNO), Utrecht, the Netherlands.
Brain Behav Immun Health. 2024 Nov 28;43:100918. doi: 10.1016/j.bbih.2024.100918. eCollection 2025 Feb.
Prebiotic dietary fiber (PDF) may reduce feelings of stress or improve mood in healthy individuals. Yet gut intervention studies that focus on mood in daily life are lacking and few studies include extensive biological sample analyses to gain mechanistic insights. As part of a larger randomized placebo-controlled crossover study including healthy individuals, we explored the effects of 12 weeks of PDF (acacia gum and carrot powder) on everyday mood, as measured with ecological momentary assessment (EMA). Microbiome composition and levels of microbial metabolites, endocrine, and inflammatory markers were determined prior to and after both intervention phases. Fifty-four participants completed the study. The intervention significantly increased daily positive affect (PA) and reduced daily negative affect (NA) in female but not male participants. The intervention-induced reduction in NA was associated with an increase in microbial diversity in female participants. The intervention did not significantly affect levels of fecal short chain fatty acids, cortisol, and inflammatory markers. This is one of the first studies to show that a dietary fiber intervention can positively alter mood as it is experienced in everyday life. Overall, our findings may stimulate more targeted gut-microbiome interventions and detection of its mental health effects in real life.
益生元膳食纤维（PDF）可能会减轻健康个体的压力感或改善情绪。然而，针对日常生活情绪的肠道干预研究较为缺乏，而且很少有研究进行广泛的生物样本分析以深入了解其作用机制。作为一项包含健康个体的更大规模随机安慰剂对照交叉研究的一部分，我们采用生态瞬时评估（EMA）方法，探究了为期12周的PDF（阿拉伯胶和胡萝卜粉）对日常情绪的影响。在两个干预阶段前后分别测定了微生物组组成、微生物代谢产物水平、内分泌和炎症标志物。54名参与者完成了该研究。干预显著增加了女性参与者的每日积极情绪（PA）并减少了每日消极情绪（NA），但对男性参与者没有此效果。干预引起的女性参与者NA减少与微生物多样性增加有关。该干预对粪便短链脂肪酸、皮质醇和炎症标志物水平没有显著影响。这是首批表明膳食纤维干预可在日常生活中积极改变情绪的研究之一。总体而言，我们的研究结果可能会推动更有针对性的肠道微生物组干预措施，并在现实生活中检测其对心理健康的影响。
