School of Psychology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK.
BaseClear, Leiden, The Netherlands.
Sci Rep. 2021 Apr 15;11(1):8302. doi: 10.1038/s41598-021-87865-w.
Current research implicates pre- and probiotic supplementation as a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike. Here we focus on the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life. We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses. We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety. Gut microbiota research has captured the imagination of the scientific and lay community alike, yet we are now at a stage where this early enthusiasm will need to be met with rigorous research in humans. Our work makes an important contribution to this effort by combining a psychobiotic intervention in a human sample with comprehensive behavioural and gut microbiota measures.
目前的研究表明，益生菌和益生元补充剂可能是改善身心疾病症状的一种手段，这使得它成为临床医生和消费者都感兴趣的一个概念。在这里，我们关注的是青少年后期到成年早期的过渡期，在此期间，通过营养补充来影响肠道微生物群的有效干预措施，有可能抵消以后生活中的与健康相关的成本。我们在一项为期 4 周的双盲、安慰剂对照的半乳糖寡糖（GOS）益生元补充干预中，对 64 名健康女性的情绪和幸福感进行了多项指标的评估，并在基线和随访时获得了粪便样本，用于肠道微生物组测序和分析。我们报告了 GOS 干预对高特质焦虑、注意力偏差和细菌丰度的自我报告的影响，这表明，用 GOS 益生元进行饮食补充可能会改善临床前焦虑的指标。肠道微生物组的研究引起了科学界和非科学界的想象力，但我们现在正处于一个需要用人类的严格研究来满足这种早期热情的阶段。我们的工作通过在人类样本中结合益生菌干预和全面的行为和肠道微生物组措施，为这一努力做出了重要贡献。
