Monga Anmol, de Moura Hector Lise, Zibetti Marcelo V W, Youm Thomas, Samuels Jonathan, Regatte Ravinder R
Center of Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, USA.
Department of Orthopedic Surgery, New York University Grossman School of Medicine, New York, New York, USA.
J Magn Reson Imaging. 2025 Jul;62(1):160-173. doi: 10.1002/jmri.29679. Epub 2024 Dec 24.
Three-dimensional MR fingerprinting (3D-MRF) has been increasingly used to assess cartilage degeneration, particularly in the knee joint, by looking into multiple relaxation parameters. A comparable 3D-MRF approach can be adapted to assess cartilage degeneration for the hip joint, with changes to accommodate specific challenges of hip joint imaging.
To demonstrate the feasibility and repeatability of 3D-MRF in the bilateral hip jointly we map proton density (PD), T, T, T, and ∆B in clinically feasible scan times.
Prospective.
Eight healthy subjects, three patients with mild osteoarthritis (OA), and one of the OA patients had femoral acetabular impingement (FAI). A National Institute of Standards and Technology/International Society for Magnetic Resonance in Medicine (NIST/ISMRM) system phantom was also used.
FIELD STRENGTH/SEQUENCE: 3 T, 3D-MRF sequence for bilateral hip joint mapping. Reference sequences include Volume Interpolated Breath-hold Examination (VIBE) for T mapping, and magnetization-prepared fast low-angle shot (TFL) for T and T mapping.
The signal-to-noise ratio (SNR), repeatability, scan time, and accuracy of T, T, and T maps of 3D-MRF sequence were evaluated on a NIST/ISMRM phantom and human subjects. Differences in the parametric maps between OA and healthy subjects were assessed.
Regression, Bland-Altman, Kruskal-Wallis, and Wilcoxon tests were used to assess for accuracy, repeatability, and subregional variation. The P-value <0.05 indicated statistically significant.
A 3D-MRF sequence sensitive to PD, T, T, T, and ∆B within 15 minutes, achieving high SNR and low test-retest coefficient of variance (T: 3.36%, T: 3.99%, T: 5.93%). Mild hip OA patients, including one with mild OA and FAI, showed elevation of 29.4 ± 9% (T) and 32.4 ± 4.4% (T) in femoral lateral compartment of the hip joint compared to healthy controls.
3D-MRF may be a feasible approach for simultaneous, quantitative mapping of bilateral hip joint cartilage in healthy and mild OA patients.
1 TECHNICAL EFFICACY: Stage 1.
三维磁共振指纹成像（3D-MRF）越来越多地用于通过研究多个弛豫参数来评估软骨退变，尤其是在膝关节中。一种类似的3D-MRF方法可适用于评估髋关节的软骨退变，并进行了一些改变以适应髋关节成像的特定挑战。
在临床可行的扫描时间内，通过绘制质子密度（PD）、T1、T2、T2*和ΔB，证明3D-MRF在双侧髋关节中的可行性和可重复性。
前瞻性研究。
8名健康受试者、3名轻度骨关节炎（OA）患者，其中1名OA患者合并股骨髋臼撞击症（FAI）。还使用了美国国家标准与技术研究院/国际医学磁共振学会（NIST/ISMRM）系统模型。
场强/序列：3T，用于双侧髋关节成像的3D-MRF序列。参考序列包括用于T1成像的容积内插屏气检查（VIBE）序列，以及用于T2和T2*成像的磁化准备快速低角度激发（TFL）序列。
在NIST/ISMRM模型和人体受试者上评估3D-MRF序列的T1、T2和T2*图的信噪比（SNR）、可重复性、扫描时间和准确性。评估OA患者与健康受试者之间参数图的差异。
采用回归分析、Bland-Altman分析、Kruskal-Wallis检验和Wilcoxon检验来评估准确性和可重复性以及亚区域差异。P值<0.05表示具有统计学意义。
一个对PD、T1、T2、T2和ΔB敏感的3D-MRF序列在15分钟内完成，实现了高SNR和低重测变异系数（T1：3.36%，T2：3.99%，T2：5.93%）。轻度髋关节OA患者，包括1名合并轻度OA和FAI的患者，与健康对照相比，髋关节股骨外侧间室的T1升高29.4±9%，T2升高32.4±4.4%。
3D-MRF可能是一种用于同时定量绘制健康和轻度OA患者双侧髋关节软骨的可行方法。
1级 技术效能：1级
