Zhu Dagny, Karki Suyen, Dhariwal Mukesh, Soini Erkki, Asseburg Christian
NVISION Eye Centers, Rowland Heights, CA, USA.
ESiOR Oy, Kuopio, Finland.
Ophthalmol Ther. 2025 Feb;14(2):379-390. doi: 10.1007/s40123-024-01085-9. Epub 2024 Dec 24.
Diffractive trifocal intraocular lenses (IOLs) provide good vision at distance, intermediate, and near, but can also cause positive dysphotopsias. This meta-analysis pooled published evidence on visual disturbances after bilateral implantation of the PanOptix (TFNTXX) IOL for patients undergoing cataract surgery.
A systematic literature search was conducted in PubMed and congress presentations from April 2021 to December 2022 to identify studies with patient-reported outcomes on the incidence of visual disturbances (starbursts, halos, glare) post bilateral implantation of PanOptix IOL during cataract surgery. Random-effects meta-analysis was performed to generate pooled proportions for patient-reported visual disturbances with a 95% confidence interval [CI].
Eleven unique studies were included, spanning 580 patients with bilateral implantation of PanOptix IOL from 10 countries with 1 to 12 months follow-up. In summary, 33.6% of patients with bilateral PanOptix implantation experienced glare, 43.9% experienced halos, and 30.4% experienced starbursts. Among these patients, small percentages reported severe glare (2.9%), severe halos (5.4%), and severe starbursts (3.4%). Only 0.8%, 1.4%, and 2.6% of patients found glare, halos, and starbursts, respectively, to be very bothersome.
Halos are the most frequently reported visual disturbances. However, the likelihood of experiencing severe and/or very bothersome visual disturbances (halos, glare, starbursts) is approximately 5% and 3%, respectively, after bilateral implantation of PanOptix IOL. These findings should inform clinical decision-making and treatment choices when selecting the most appropriate IOL implant for cataract surgery.
衍射型三焦点人工晶状体（IOL）可提供良好的远、中、近视力，但也可能导致正向视幻觉。本荟萃分析汇总了已发表的关于白内障手术患者双侧植入PanOptix（TFNTXX）IOL后视觉障碍的证据。
于2021年4月至2022年12月在PubMed和会议报告中进行系统文献检索，以确定有关白内障手术期间双侧植入PanOptix IOL后患者报告的视觉障碍（星芒、光晕、眩光）发生率的研究。采用随机效应荟萃分析来生成患者报告的视觉障碍合并比例及95%置信区间[CI]。
纳入了11项独特研究，涉及来自10个国家的580例双侧植入PanOptix IOL的患者，随访时间为1至12个月。总体而言，双侧植入PanOptix的患者中，33.6%经历过眩光，43.9%经历过光晕，30.4%经历过星芒。在这些患者中，小部分报告有严重眩光（2.9%）、严重光晕（5.4%）和严重星芒（3.4%）。分别只有0.8%、1.4%和2.6%的患者认为眩光、光晕和星芒非常困扰。
光晕是最常报告的视觉障碍。然而，双侧植入PanOptix IOL后，出现严重和/或非常困扰的视觉障碍（光晕、眩光、星芒）的可能性分别约为5%和3%。这些发现应为白内障手术选择最合适的IOL植入物时的临床决策和治疗选择提供参考。
