van Slingerland Kim, Kranenburg Laura J C, Wilmsen Nathalie, Coles Emma, Dolhain Radboud J E M, de Jong Pascal H P
Department of Rheumatology, Erasmus MC, Rotterdam, The Netherlands.
Voeding Leeft, Amsterdam, The Netherlands.
Rheumatology (Oxford). 2025 Jun 1;64(6):3309-3318. doi: 10.1093/rheumatology/keae696.
To evaluate the short- and long-term effects of an online, interactive, multifactorial lifestyle intervention programme (Leef! Met Reuma) on health risk and all ICHOM-recommended patient-reported outcome measures (PROMs) in patients with an inflammatory arthritis (IA), osteoarthritis (OA) or fibromyalgia (FM).
Patients with an IA, OA or FM could register for the lifestyle intervention programme. The programme consists of a 3-month intensive part followed by a 21-month aftercare period and focuses on four pillars, namely nutrition, exercise, relaxation and sleep. Health risk and PROMs are collected 3-monthly during the first 6 months and 6-monthly during the next 18 months. Health risk includes self-reported weight, waist circumference and BMI. Following PROMs were included: pain, morning stiffness severity, fatigue, Health Assessment Questionnaire, quality of life, perceived stress, sleep disturbance and impact on life. Descriptive statistics were used to assess the change in health risk and PROMs during the intensive part of the programme and aftercare period.
Of the 264 patients studied, 88, 105 and 71 were diagnosed with IA, OA and FM, respectively. Health risk significantly improved in all three diagnosis groups during the intensive part of the programme. The mean BMI reduction was -1.36 (0.26), -1.22 (0.23) and -1.48 (0.33), whereafter it stabilized in the aftercare period. All PROMs showed a similar trend.
An online, interactive lifestyle intervention programme has a positive long-term effect, even after 2 years of follow-up, on health risk and all PRO domains in patients with an IA, OA and FM.
评估一项在线、交互式、多因素生活方式干预计划（Leef! Met Reuma）对炎性关节炎（IA）、骨关节炎（OA）或纤维肌痛（FM）患者健康风险及所有国际健康结局测量标准（ICHOM）推荐的患者报告结局指标（PROMs）的短期和长期影响。
IA、OA或FM患者可报名参加该生活方式干预计划。该计划包括为期3个月的强化阶段，随后是21个月的后续护理期，重点关注四个方面，即营养、运动、放松和睡眠。在最初6个月内每3个月收集一次健康风险和PROMs数据，在接下来18个月内每6个月收集一次。健康风险包括自我报告的体重、腰围和体重指数。纳入的PROMs指标如下：疼痛、晨僵严重程度、疲劳、健康评估问卷、生活质量、感知压力、睡眠障碍及对生活的影响。采用描述性统计方法评估该计划强化阶段和后续护理期内健康风险和PROMs的变化。
在研究的264例患者中，分别有88例、105例和71例被诊断为IA、OA和FM。在该计划的强化阶段，所有三个诊断组的健康风险均有显著改善。平均体重指数降低分别为-1.36（0.26）、-1.22（0.23）和-1.48（0.33），之后在后续护理期趋于稳定。所有PROMs指标均呈现类似趋势。
一项在线、交互式生活方式干预计划，即使在随访2年后，对IA、OA和FM患者的健康风险及所有PROMs领域仍有积极的长期影响。
