Spalgais Sonam, Ranga Vikrant, Mavi Anil K, Kumar Raj
Department of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
Respiratory Medicine, Dr. Prem Superspeciality and Cancer Hospital, Panipat, Haryana, India.
Lung India. 2025 Jan 1;42(1):11-15. doi: 10.4103/lungindia.lungindia_205_24. Epub 2024 Dec 24.
Bird fancier's disease is a type of HP occurring due to exposure to bird's antigen. The diagnosis is quite difficult as it requires the identification of an inciting agent with findings of HRCT and lung biopsy. The exposure is usually done by history with antigen-specific IgG and/or specific inhalational challenge testing. The study aimed to investigate the role of pigeon allergens in house dust in bird exposure-related HP patients.
This was a descriptive, mixed-method observational study. We retrospectively screened all the files of HP patients for exposure history and pigeon-specific IgG of one-year duration. Finally, Finally house dust from 18 cases with HP was collected for analysis of concentration of pigeon droppings and feather proteins.
The mean age was 47.8 ± 11.5 years with 78% being female. The median duration of symptoms was 1.75 years with a median exposure history to pigeons of 7 years. The level of specific IgG was raised in 11 (60%) patients with a mean level of 50.6 ± 39.5. The concentration of pigeon-drooping protein was present in all the dust samples with a mean of 17.6 ± 5.6 μg/mg. The highest concentration was 27 μg/mg and the lowest of 9 μg/mg. The concentration of pigeon father protein was present in nearly 50% of the dust sample with a mean of 5.6 ± 6.7 μg/mg and the highest concentration was 15.8 μg/mg.
The confirmation history of exposure in bird exposure-related HP is difficult because bird antigen exposure can be presents anywhere. The house dust bird protein concentration measurement is a simple, non-invasive, adjunct test for confirmation of bird exposure.
养鸟人肺是一种因接触鸟类抗原而发生的过敏性肺炎。诊断相当困难，因为它需要通过高分辨率计算机断层扫描（HRCT）和肺活检结果来识别致病因素。通常通过病史、抗原特异性IgG和/或特异性吸入激发试验来确定接触情况。本研究旨在调查鸽过敏原在与鸟类接触相关的养鸟人肺患者家庭灰尘中的作用。
这是一项描述性的混合方法观察性研究。我们回顾性筛查了所有养鸟人肺患者的病历，以获取为期一年的接触史和鸽特异性IgG。最后，收集了18例养鸟人肺患者的家庭灰尘，用于分析鸽粪和羽毛蛋白的浓度。
平均年龄为47.8±11.5岁，78%为女性。症状的中位持续时间为1.75年，接触鸽子的中位病史为7年。11例（60%）患者的特异性IgG水平升高，平均水平为50.6±39.5。所有灰尘样本中均存在鸽粪蛋白浓度，平均为17.6±5.6μg/mg。最高浓度为27μg/mg，最低浓度为9μg/mg。近50%的灰尘样本中存在鸽羽蛋白浓度，平均为5.6±6.7μg/mg，最高浓度为15.8μg/mg。
在与鸟类接触相关的养鸟人肺中，确认接触史很困难，因为鸟类抗原接触可能出现在任何地方。家庭灰尘中鸟类蛋白浓度的测量是一种简单、无创的辅助检测方法，用于确认鸟类接触情况。
