Maheshwari Nisha, Marone Alessandro, Kim Stephen H K, Bajakian Danielle R, Hielscher Andreas H
New York University, Tandon School of Engineering, Department of Biomedical Engineering, New York, United States.
Columbia University, Irving Medical Center, Division of Vascular Surgery and Endovascular Intervention, Department of Surgery, New York, United States.
J Biomed Opt. 2024 Dec;29(12):127001. doi: 10.1117/1.JBO.29.12.127001. Epub 2024 Dec 24.
Tracking changes in the vasculature of patients with peripheral arterial disease (PAD) may identify the need for follow-up treatment within only weeks after an initial intervention, enabling timely support and improving patient outcomes.
We aim to evaluate dynamic vascular optical spectroscopy's (DVOS's) ability to accurately monitor the hemodynamics of affected arteries in patients with PAD after a surgical intervention and predict long-term clinical outcomes.
A DVOS system non-invasively monitored the blood flow through 256 lower extremity arteries in 80 PAD patients immediately before, immediately after, and 3 to 4 weeks after they underwent a surgical intervention.
Hemodynamic changes measured by DVOS after a revascularization procedure (RP) classified patient long-term ( months) outcomes with high accuracy [81.6% for patients with ulcers ( ); 81.1% for patients without ulcers ( )] by 3 to 4 weeks after the RP, outperforming available ankle-brachial index and ultrasound measurements. In addition, DVOS parameters distinguished between patients who underwent only a catheter angiography (CA) and patients who underwent both a CA and RP ( ).
The DVOS system was able to classify patient long-term clinical outcomes with high accuracy within one month after an RP and distinguish among different interventions. DVOS may be a promising alternative or adjunct to existing monitoring approaches.
追踪外周动脉疾病（PAD）患者血管系统的变化，可能仅在初次干预后数周内就能确定是否需要后续治疗，从而实现及时支持并改善患者预后。
我们旨在评估动态血管光学光谱法（DVOS）在手术干预后准确监测PAD患者患侧动脉血流动力学并预测长期临床结局的能力。
一个DVOS系统在80例PAD患者接受手术干预前、干预后即刻以及干预后3至4周，对其256条下肢动脉的血流进行无创监测。
血管重建术（RP）后通过DVOS测量的血流动力学变化，在RP后3至4周时能以高精度对患者的长期（数月）结局进行分类[溃疡患者为81.6%（ ）；无溃疡患者为81.1%（ ）]，优于现有的踝肱指数和超声测量。此外，DVOS参数能够区分仅接受导管血管造影（CA）的患者和同时接受CA及RP的患者（ ）。
DVOS系统能够在RP后一个月内以高精度对患者的长期临床结局进行分类，并区分不同的干预措施。DVOS可能是现有监测方法的一种有前景的替代或辅助手段。
