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采用动态血管光学光谱技术对周围动脉疾病伤口愈合进行术后监测。

Postintervention monitoring of peripheral arterial disease wound healing using dynamic vascular optical spectroscopy.

机构信息

New York University, Department of Biomedical Engineering, New York, United States.

Memorial Sloan Kettering Cancer Center, New York, United States.

出版信息

J Biomed Opt. 2022 Dec;27(12):125002. doi: 10.1117/1.JBO.27.12.125002. Epub 2022 Dec 24.

DOI:10.1117/1.JBO.27.12.125002
PMID:36582192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9789744/
Abstract

SIGNIFICANCE

Due to the persistence of chronic wounds, a second surgical intervention is often necessary for patients with peripheral arterial disease (PAD) within a year of the first intervention. The dynamic vascular optical spectroscopy system (DVOS) may assist physicians in determining patient prognosis only a month after the first surgical intervention.

AIM

We aim to assess the DVOS utility in characterizing wound healing in PAD patients after endovascular intervention.

APPROACH

The DVOS used near-infrared light ( ) to record hemodynamic response to a cuff inflation in 14 PAD patients with lower limb ulcers immediately before, immediately after, and at a first follow-up 3 to 4 weeks after intervention. Ankle-brachial index (ABI) and arterial duplex ultrasound (A-DUS) measurements were obtained when possible.

RESULTS

The total hemoglobin plateau time differed significantly between patients with ulcers that reduced in size ( ) and patients with ulcers that did not ( ) 3 to 4 weeks after intervention ( ). Data correlated strongly (89% sensitivity, 100% specificity, and ) with long-term wound healing. ABI and A-DUS measurements were not statistically associated with wound healing.

CONCLUSIONS

This pilot study demonstrates the potential of the DVOS to aid physicians in giving accurate long-term wound healing prognoses 1 month after intervention.

摘要

意义

由于慢性伤口的持续存在，外周动脉疾病 (PAD) 患者在第一次干预后的一年内，往往需要进行第二次手术干预。动态血管光学光谱系统 (DVOS) 可能有助于医生在第一次手术干预后仅一个月就确定患者的预后。

目的

我们旨在评估 DVOS 在评估血管内介入治疗后 PAD 患者伤口愈合情况方面的效用。

方法

该研究使用近红外光 ( ) 记录了 14 例下肢溃疡的 PAD 患者在介入治疗前、介入治疗后即刻和治疗后 3 至 4 周首次随访时的 cuff 充气的血流动力学反应。尽可能获得踝肱指数 (ABI) 和动脉双功能超声 (A-DUS) 测量值。

结果

干预后 3 至 4 周，溃疡缩小的患者（ ）与溃疡未缩小的患者（ ）的总血红蛋白平台时间差异有统计学意义（ ）。该数据与长期伤口愈合具有很强的相关性（89%的敏感性、100%的特异性和 ）。ABI 和 A-DUS 测量值与伤口愈合无统计学关联。

结论

这项初步研究表明，DVOS 有可能帮助医生在干预后 1 个月对长期伤口愈合做出准确的预后判断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c37f/9789744/8d9db79aae4b/JBO-027-125002-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c37f/9789744/dfcf9e889fd0/JBO-027-125002-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c37f/9789744/a0503b45f072/JBO-027-125002-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c37f/9789744/96907c4022c7/JBO-027-125002-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c37f/9789744/8d9db79aae4b/JBO-027-125002-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c37f/9789744/dfcf9e889fd0/JBO-027-125002-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c37f/9789744/a0503b45f072/JBO-027-125002-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c37f/9789744/96907c4022c7/JBO-027-125002-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c37f/9789744/8d9db79aae4b/JBO-027-125002-g004.jpg

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