Pertovaara A, Kojo I
Exp Neurol. 1985 Mar;87(3):439-45. doi: 10.1016/0014-4886(85)90174-8.
Thermal thresholds (cool, warm, heat, heat pain) were determined in four skin regions (cheek, glabrous skin of the hand, hairy forearm, leg) of eight healthy human subjects. The thermostimulator was composed of Peltier elements and three rates of continuous stimulation were used: 1.4, 2.4, and 3.9 degrees C/s. Warm, heat, and heat pain thresholds increased with increasing rate of temperature change, and the increase was of equal magnitude with these three thresholds. However, the effect of increasing stimulus rate on cool thresholds was nonsignificant. Similar results were obtained in all skin regions studied. It is suggested that liminal warm, heat, and heat pain sensations are mediated by afferent fibers with conduction velocities of the same range (C-fibers) whereas liminal cool sensations are signaled by faster conducting afferent fibers.
在8名健康人体受试者的四个皮肤区域（脸颊、手部无毛皮肤、有毛前臂、腿部）测定了热阈值（冷、温、热、热痛）。热刺激器由珀耳帖元件组成，并使用了三种连续刺激速率：1.4、2.4和3.9摄氏度/秒。温、热和热痛阈值随温度变化速率的增加而升高，且这三个阈值的升高幅度相同。然而，刺激速率增加对冷阈值的影响不显著。在所有研究的皮肤区域都得到了类似的结果。有人提出，阈下温、热和热痛感觉是由传导速度在同一范围的传入纤维（C类纤维）介导的，而阈下冷感觉是由传导速度更快的传入纤维发出信号的。
