Guha Soumya Kanti, Niyogi Sougata
Department of Computer Application, Dinabandhu Andrews Institute of Technology and Management, BaishnabghataPatuli Township, Block-S, 1/406A, Near Satyajit Ray Park, Patuli, Kolkata, West Bengal, 700094, India.
Department of Medical Laboratory Technology, Dinabandhu Andrews Institute of Technology and Management, BaishnabghataPatuli Township, Block-S, 1/406A, Near Satyajit Ray Park, Patuli, Kolkata, West Bengal, 700094, India.
Curr Microbiol. 2024 Dec 25;82(1):59. doi: 10.1007/s00284-024-04041-9.
This review explores the bidirectional relationship between the human microbiome and SARS-CoV-2 infection, elucidating its implications for COVID-19 susceptibility, severity, and therapeutic strategies. Metagenomic analyses reveal notable alterations in microbiome composition associated with SARS-CoV-2 infection, impacting disease severity and clinical outcomes. Dysbiosis within the respiratory, gastrointestinal, oral, and skin microbiomes exacerbates COVID-19 pathology through immune dysregulation and inflammatory pathways. Understanding these microbial shifts is pivotal for devising targeted therapeutic interventions. Notably, co-infection of oral pathogens with SARS-CoV-2 worsens lung pathology, while gut microbiome dysbiosis influences viral susceptibility and severity. Potential therapeutic approaches targeting the microbiome include probiotics, antimicrobial agents, and immunomodulatory strategies. This review underscores the importance of elucidating host-microbiota interactions to advance precision medicine and public health initiatives in combating COVID-19 and other infectious diseases.
本综述探讨了人类微生物组与SARS-CoV-2感染之间的双向关系，阐明了其对COVID-19易感性、严重程度和治疗策略的影响。宏基因组分析揭示了与SARS-CoV-2感染相关的微生物组组成的显著变化，影响疾病严重程度和临床结果。呼吸道、胃肠道、口腔和皮肤微生物组的生态失调通过免疫失调和炎症途径加剧了COVID-19的病理过程。了解这些微生物变化对于制定有针对性的治疗干预措施至关重要。值得注意的是，口腔病原体与SARS-CoV-2的共同感染会加重肺部病理，而肠道微生物组失调会影响病毒易感性和严重程度。针对微生物组的潜在治疗方法包括益生菌、抗菌剂和免疫调节策略。本综述强调了阐明宿主-微生物群相互作用对于推进精准医学和公共卫生举措以对抗COVID-19和其他传染病的重要性。
