Druart Mélanie, Kori Megha, Chaimowitz Corryn, Fan Catherine, Sippy Tanya
Department of Psychiatry and Neuroscience & Physiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Department of Psychiatry and Neuroscience & Physiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Cell Rep. 2025 Jan 28;44(1):115090. doi: 10.1016/j.celrep.2024.115090. Epub 2024 Dec 24.
The posterior "tail" region of the striatum receives dense innervation from sensory brain regions and is important for behaviors that require sensorimotor integration. The output neurons of the striatum, D1 and D2 striatal projection neurons (SPNs), which make up the direct and indirect pathways, are thought to play distinct functional roles, although it remains unclear if these neurons show cell-type-specific differences in their response to sensory stimuli. Here, we examine the strength of synaptic inputs onto D1 and D2 SPNs following the stimulation of upstream auditory pathways. We report that auditory-evoked depolarizations onto D1 SPN responses are stronger and faster. This is due to differences in feedforward inhibition, with fast-spiking interneurons forming stronger synapses onto D2 SPNs. Our results support a model in which differences in feedforward inhibition enable the preferential recruitment of D1 SPNs by auditory stimuli, positioning the direct pathway to initiate sound-driven actions.
纹状体的后部“尾状”区域接受来自感觉脑区的密集神经支配，对于需要感觉运动整合的行为很重要。纹状体的输出神经元，即构成直接和间接通路的D1和D2纹状体投射神经元（SPN），被认为发挥着不同的功能作用，尽管尚不清楚这些神经元在对感觉刺激的反应中是否表现出细胞类型特异性差异。在这里，我们研究了上游听觉通路刺激后D1和D2 SPN上突触输入的强度。我们报告说，听觉诱发的D1 SPN反应去极化更强且更快。这是由于前馈抑制的差异，快速放电中间神经元在D2 SPN上形成更强的突触。我们的结果支持一种模型，其中前馈抑制的差异使得听觉刺激能够优先募集D1 SPN，使直接通路能够启动声音驱动的动作。
