染色质纤维结构的三螺旋模型。
A triple helix model for the structure of chromatin fiber.
作者信息
Makarov V, Dimitrov S, Smirnov V, Pashev I
出版信息
FEBS Lett. 1985 Feb 25;181(2):357-61. doi: 10.1016/0014-5793(85)80292-1.
A model of chromatin fiber structure is presented in which a repeating unit of a trinucleosome forms a 3-dimensional zigzag. Twisting and compression of the zigzag result in a triple helix structure. The model is built mainly on the flow linear dichroism data showing that nucleosomal disc faces are tilted relative to the fiber axis, the orientation of nucleosomes does not change upon folding and unfolding of chromatin, and the orientation of nucleosomes is maintained by the globular domain of histone H1.
提出了一种染色质纤维结构模型，其中三核小体的重复单元形成三维锯齿状结构。锯齿状结构的扭曲和压缩产生三螺旋结构。该模型主要基于流动线性二色性数据构建，这些数据表明核小体盘面对纤维轴倾斜，染色质折叠和解折叠时核小体的方向不变，并且核小体的方向由组蛋白H1的球状结构域维持。
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