全氟辛酸（PFOA）、全氟辛烷磺酸（PFOS）和全氟己烷磺酸（PFHxS）的毒代动力学考量，用于开发一种体内方法以评估土壤中全氟烷基和多氟烷基物质（PFAS）的相对生物利用度。
PFOA, PFOS and PFHxS toxicokinetic considerations for the development of an in vivo approach for assessing PFAS relative bioavailability in soil.
作者信息
Juhasz Albert L, Kastury Farzana, Jones Ruby, Seeborun Mahima, Caceres Tanya, Herde Carina, Cavallaro Michelle, Dilmetz Sarah, Hutchings Joshua, Grebneva Yevgeniya, Desire Chris, Hoffmann Peter
机构信息
Future Industries Institute, UniSA STEM, University of South Australia, Mawson Lakes Campus, 5095, Australia.
Future Industries Institute, UniSA STEM, University of South Australia, Mawson Lakes Campus, 5095, Australia.
出版信息
Environ Int. 2025 Jan;195:109232. doi: 10.1016/j.envint.2024.109232. Epub 2024 Dec 20.
A Sprague-Dawley rat model was utilized to elucidate perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) toxicokinetics with a goal of developing an in vivo approach for quantifying PFAS relative bioavailability in impacted soil. Following single dose administration (gavage) of ∼ 0.2-2000 µg kg BW of PFOA, PFOS or PFHxS, differences in PFAS blood, organ and excreta concentrations were observed over 120 h although linear dose responses were determined for area under the blood plasma time curves (AUC; PFOA, PFHxS), liver accumulation (LA: PFOS) and urinary excretion (UE; PFOA, PFHxS). Oral and intravenous dose (∼20 µg kg body weight) comparisons highlighted the high absolute bioavailability of PFOA (AUC: 100.3 ± 23.4 %; UE: 94.7 ± 26.6 %), PFOS (LA: 102.9 ± 15.6 %) and PFHxS (AUC: 88.3 ± 15.1 %; UE: 90.9 ± 7.3 %). Two spiked (C-PFOA: 4360 ± 218 µg kg) and two PFAS impacted soils (PFOS: 1880-2250 µg kg; PFHxS: 61.2-65.5 µg kg) were utilized to measure PFAS relative bioavailability in soil matrices. In all soils, PFAS relative bioavailability was > 86 % (PFOA: 87.0-90.9 %; PFOS: 86.1-90.4 %; PFHxS: 86.5-97.0 %) although the method could quantify bioavailability reductions (25.6-88.9 %) when hydrophobic and electrostatic interactions were enhanced through the addition of carbon-based amendments (5-10 % w/w).
利用Sprague-Dawley大鼠模型来阐明全氟辛酸（PFOA）、全氟辛烷磺酸（PFOS）和全氟己烷磺酸（PFHxS）的毒代动力学，目的是开发一种体内方法来量化受污染土壤中全氟辛烷磺酸（PFAS）的相对生物利用度。在单次给药（灌胃）约0.2 - 2000 µg/kg体重的PFOA、PFOS或PFHxS后，尽管血浆时间曲线下面积（AUC；PFOA、PFHxS）、肝脏蓄积（LA：PFOS）和尿排泄（UE；PFOA、PFHxS）呈现线性剂量反应，但在120小时内观察到PFAS在血液、器官和排泄物中的浓度存在差异。口服和静脉给药（约20 µg/kg体重）比较突出了PFOA（AUC：100.3 ± 23.4%；UE：94.7 ± 26.6%）、PFOS（LA：102.9 ± 15.6%）和PFHxS（AUC：88.3 ± 15.1%；UE：90.9 ± 7.3%）的高绝对生物利用度。使用两种加标土壤（C-PFOA：4360 ± 218 µg/kg）和两种受PFAS污染的土壤（PFOS：1880 - 2250 µg/kg；PFHxS：61.2 - 65.5 µg/kg）来测量土壤基质中PFAS的相对生物利用度。在所有土壤中，PFAS的相对生物利用度均> 86%（PFOA：87.0 - 90.9%；PFOS：86.1 - 90.4%；PFHxS：86.5 - 97.0%），尽管当通过添加碳基改良剂（5 - 10% w/w）增强疏水和静电相互作用时，该方法可以量化生物利用度的降低（25.6 - 88.9%）。
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