Sato Toshihiro, Tsujimoto Tetsuro, Kobayashi Michi, Kajio Hiroshi
Department of Diabetes, Endocrinology, and Metabolism, National Center for Global Health and Medicine, Japan.
Department Diabetes, Metabolism and Endocrinology, Tohoku University graduate school of medicine, Japan.
Intern Med. 2025 Jul 15;64(14):2192-2196. doi: 10.2169/internalmedicine.4648-24. Epub 2024 Dec 26.
There are no clear strategies for non-insulin-dependent slowly progressive type 1 diabetes mellitus (SPIDDM). We herein report a 25-year-old man with SPIDDM in whom appropriate diet therapy and exercise improved the initial insulin secretion without medication. After 12 months, his body weight decreased by 5.4 kg, and his muscle mass increased from 0.77 to 0.81 kg/body weight. Glycated hemoglobin levels were reduced from 6.4% to 5.7%. HOMA-IR decreased from 1.70 to 0.77; in particular, the insulinogenic index improved from 0.04 to 0.13. These improvements were maintained over five years with continuous lifestyle interventions. Patients with non-insulin-dependent SPIDDM may recover and retain their insulin secretion through lifestyle interventions.
对于非胰岛素依赖型缓慢进展性1型糖尿病（SPIDDM），目前尚无明确的治疗策略。我们在此报告一名25岁的SPIDDM男性患者，通过适当的饮食治疗和运动，在未使用药物的情况下改善了初始胰岛素分泌。12个月后，他的体重下降了5.4千克，肌肉量从0.77千克/体重增加到0.81千克/体重。糖化血红蛋白水平从6.4%降至5.7%。HOMA-IR从1.70降至0.77；特别是胰岛素生成指数从0.04提高到0.13。通过持续的生活方式干预，这些改善在五年内得以维持。非胰岛素依赖型SPIDDM患者可能通过生活方式干预恢复并保留其胰岛素分泌。
