Haghani Iman, Saeedi Majid, Babaei Amirhossein, Yahyazadeh Zahra, Hosseinnataj Abolfazl, Ebrahimi Saravi Mohammad, Akbari Fatemeh, Lotfizadeh Anahita, Rajabi Visroodi Ehsan, Molania Tahereh
Assistant Professor, Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran; and Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Professor, Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
J Prosthet Dent. 2025 Feb;133(2):481.e1-481.e8. doi: 10.1016/j.prosdent.2024.12.003. Epub 2024 Dec 24.
Denture stomatitis (DS) is a common oral disorder in patients with complete maxillary dentures. Typical treatments such as nystatin or azoles lead to drug resistance after a long period. Several studies have shown the antifungal activity of statins against Candida albicans; however, studies on the antifungal effect of atorvastatin against DS are lacking.
The purpose of this randomized, double-blind controlled trial was to assess the effectiveness of atorvastatin mouthwash against DS.
Twenty-two participants diagnosed with DS were randomly allocated into 2 groups: 11 in the intervention group (atorvastatin mouthwash) and 11 in the control group (nystatin). Participants were asked to use the mouthwash 3 times a day for 2 weeks. The length and width of the lesions were measured, and the number of colonies were counted on days 1 and 14. Data were analyzed with the Spearman correlation coefficient and the Mann-Whitney, Kruskal Wallis, and Wilcoxon tests (α=.05).
The number of colonies before and after using a mouthwash was significantly different in the control and intervention groups (P=.005 and P=.003, respectively). The number of colonies in the 2 groups were statistically similar on the first day (P=.809). However, a significant difference was observed between the groups on day 14 (P=.024). The number of colonies in the atorvastatin group decreased more than nystatin, indicating that atorvastatin was more effective. A significant difference among the groups was found in terms of Candida species detected after the intervention (P=.032).
Atorvastatin was effective in reducing Candida species in participants with DS and can be used as an antifungal agent in treating DS.
义齿性口炎（DS）是全口上颌义齿患者常见的口腔疾病。制霉菌素或唑类等传统治疗方法长期使用后会产生耐药性。多项研究表明他汀类药物对白色念珠菌具有抗真菌活性；然而，关于阿托伐他汀对DS抗真菌作用的研究尚缺乏。
本随机双盲对照试验旨在评估阿托伐他汀漱口水对DS的疗效。
22名被诊断为DS的参与者被随机分为两组：干预组（阿托伐他汀漱口水）11名，对照组（制霉菌素）11名。参与者被要求每天使用漱口水3次，持续2周。在第1天和第14天测量病变的长度和宽度，并计算菌落数。数据采用Spearman相关系数以及Mann-Whitney、Kruskal Wallis和Wilcoxon检验进行分析（α = 0.05）。
对照组和干预组使用漱口水前后的菌落数有显著差异（分别为P = 0.005和P = 0.003）。两组在第1天的菌落数在统计学上相似（P = 0.809）。然而，在第14天两组之间观察到显著差异（P = 0.024）。阿托伐他汀组的菌落数比制霉菌素组减少得更多，表明阿托伐他汀更有效。干预后检测到的念珠菌种类在组间存在显著差异（P = 0.032）。
阿托伐他汀对减少DS患者的念珠菌种类有效，可作为治疗DS的抗真菌药物。
