Departament of Dental Materials and Prosthodontics, Araraquara Dental School, UNESP - Univ. Estadual Paulista, Araraquara, SP, Brazil.
J Oral Rehabil. 2013 May;40(5):375-80. doi: 10.1111/joor.12039. Epub 2013 Feb 26.
This study compared the effectiveness of Ricinus communis (RC) with Nystatin (NYS) and Miconazole (MIC) in the treatment of institutionalised elderly with denture stomatitis (DS). They (n = 30) were randomly distributed into three groups: MIC, NYS or RC. Clinical and mycological evaluations were performed prior to the use of the antifungal (baseline) and repeated after 15 and 30 days of treatment. The sample was clinically examined for oral mucosal conditions. Standard photographs were taken of the palate, and the oral candidiasis was classified (Newton's criteria). Mycological investigation was performed by swabbing the palatal mucosa, and Candida spp. were quantified by counting the number of colony-forming units (cfu mL⁻¹). The clinical and mycological data were analysed, respectively by Wilcoxon and Student's t-test (α = 0.05). Significant improvement in the clinical appearance of DS in the MIC and RC groups was observed between the 1st and 3rd collections (MIC - P = 0.018; RC - P = 0.011) as well as between the 2nd and 3rd collections (MIC - P = 0.018; RC - P = 0.011). Neither groups showed a statistically significant reduction in cfu mL⁻¹ at any time. Although none of the treatments decreased the cfu mL⁻¹, it was concluded that Ricinus communis can improve the clinical condition of denture stomatitis in institutionalised elderly patients, showing similar results to Miconazole.
本研究比较了蓖麻子（RC）与制霉菌素（NYS）和咪康唑（MIC）在治疗机构化老年人口腔义齿性口炎（DS）中的疗效。他们（n = 30）被随机分为三组：MIC、NYS 或 RC。在使用抗真菌药物（基线）之前和治疗 15 天和 30 天后进行临床和真菌学评估。对口腔黏膜状况进行了临床检查。对腭部进行了标准拍照，并根据牛顿标准对口腔念珠菌病进行分类。通过擦拭腭黏膜进行真菌学研究，并通过计数形成菌落的单位数（cfu mL⁻¹）来定量 Candida spp。分别通过 Wilcoxon 和 Student's t 检验（α = 0.05）对临床和真菌学数据进行分析。在第 1 次和第 3 次收集时，MIC 和 RC 组的 DS 临床症状明显改善（MIC-P = 0.018；RC-P = 0.011），以及在第 2 次和第 3 次收集时（MIC-P = 0.018；RC-P = 0.011）。在任何时间点，两组的 cfu mL⁻¹均未显示出统计学上的显著减少。虽然这些治疗都没有降低 cfu mL⁻¹，但可以得出结论，蓖麻子可以改善机构化老年人口腔义齿性口炎的临床状况，与咪康唑的效果相似。
