Department of Oral Medicine, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Gerodontology. 2012 Jun;29(2):e680-4. doi: 10.1111/j.1741-2358.2011.00544.x. Epub 2011 Nov 30.
Denture stomatitis (DS) is the most common form of chronic oral candidiasis. The standard treatment for DS is nystatin, which is accompanied with complications such as a bitter taste. The aim of this study was to compare the effect of garlic with nystatin in DS.
This randomised clinical trial study was performed on 40 patients with DS. After obtaining written consent, patients were divided into two groups while members of each group were given either nystatin or garlic extract for 4 weeks. The length and width of erythema area was measured at the end of the first, second, third, and the fourth weeks using a calliper. Data were analysed by SPSS and statistical tests including variance analysis with anova repeated measures, chi-square, and least square differences.
The changes in the length and width of erythema at different times according to the type of treatment were found to be significant while an accelerated recovery was demonstrated for nystatin (p < 0.001). Both regimens resulted in significant recovery (p < 0.0001). Greater satisfaction with the use of garlic rather than nystatin was mentioned (p < 0.0001).
Considering the efficacy of garlic and lack of side effects for this compound and also regarding the nystatin-associated complications, garlic extract can be introduced as a substitution for standard treatment in DS.
义齿性口炎（DS）是最常见的慢性口腔假丝酵母菌病。DS 的标准治疗方法是使用制霉菌素，但这种药物会伴有苦味等并发症。本研究旨在比较大蒜与制霉菌素治疗 DS 的效果。
这是一项随机临床试验研究，共纳入 40 名 DS 患者。在获得书面同意后，将患者分为两组，每组分别给予制霉菌素或大蒜提取物治疗 4 周。在第 1、2、3 和 4 周结束时，使用卡尺测量红斑区域的长度和宽度。使用 SPSS 软件对数据进行分析，采用方差分析重复测量、卡方检验和最小二乘法差异检验进行统计分析。
不同治疗类型下红斑长度和宽度的变化均具有统计学意义，制霉菌素治疗组的恢复速度更快（p<0.001）。两种方案均显著恢复（p<0.0001）。与使用制霉菌素相比，患者对使用大蒜的满意度更高（p<0.0001）。
考虑到大蒜的疗效和这种化合物无副作用，以及制霉菌素相关的并发症，大蒜提取物可作为 DS 标准治疗的替代方法。
