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Advances in Single-Cell Sequencing and Spatial Profiling of Kidney Disease.肾脏疾病单细胞测序与空间分析的进展
Am J Pathol. 2025 Jan;195(1):5-6. doi: 10.1016/j.ajpath.2024.10.010.
2
Progress and applications of single-cell RNA sequencing and spatial transcriptome technology in acute kidney injury research.单细胞RNA测序和空间转录组技术在急性肾损伤研究中的进展与应用
Mol Ther Nucleic Acids. 2025 May 30;36(3):102583. doi: 10.1016/j.omtn.2025.102583. eCollection 2025 Sep 9.
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Single cell sequencing and spatial multiomics of diabetic kidney segmentation insights zonation-specific therapeutic metabolic pathways.糖尿病肾脏分割的单细胞测序和空间多组学揭示了特定区域的治疗性代谢途径。
Cell Insight. 2025 May 13;4(3):100252. doi: 10.1016/j.cellin.2025.100252. eCollection 2025 Jun.
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Single cell spatial transcriptomic profiling of childhood-onset lupus nephritis reveals complex interactions between kidney stroma and infiltrating immune cells.儿童期狼疮性肾炎的单细胞空间转录组分析揭示了肾基质与浸润免疫细胞之间的复杂相互作用。
bioRxiv. 2023 Nov 13:2023.11.09.566503. doi: 10.1101/2023.11.09.566503.
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Linking transcriptome and morphology in bone cells at cellular resolution with generative AI.利用生成式人工智能在细胞分辨率下将骨细胞中的转录组与形态学联系起来。
J Bone Miner Res. 2024 Dec 31;40(1):20-26. doi: 10.1093/jbmr/zjae151.
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Discovering molecular signatures in kidney transplant biopsies with borderline changes and isolated V-lesions: single-cell RNA-sequencing analysis of human blood and tissue Spatial transcriptomics.在具有临界变化和孤立V病变的肾移植活检中发现分子特征：人血液和组织空间转录组学的单细胞RNA测序分析
Sci Rep. 2025 Jul 3;15(1):23770. doi: 10.1038/s41598-025-05191-x.
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Deciphering the tumor immune microenvironment: single-cell and spatial transcriptomic insights into cervical cancer fibroblasts.解析肿瘤免疫微环境：对宫颈癌成纤维细胞的单细胞和空间转录组学见解
J Exp Clin Cancer Res. 2025 Jul 5;44(1):194. doi: 10.1186/s13046-025-03432-5.
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The spatial and single-cell landscape of skin: Charting the multiscale regulation of skin immune function.皮肤的空间与单细胞景观：绘制皮肤免疫功能的多尺度调控图谱。
Semin Immunol. 2025 Jun;78:101958. doi: 10.1016/j.smim.2025.101958. Epub 2025 Apr 22.
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Single-cell and spatial transcriptome analyses reveal MAZ(+) NPC-like clusters as key role contributing to glioma recurrence and drug resistance.单细胞和空间转录组分析揭示MAZ(+)神经祖细胞样簇是导致胶质瘤复发和耐药的关键因素。
J Transl Med. 2025 Jun 16;23(1):657. doi: 10.1186/s12967-025-06706-w.
本文引用的文献
1
The Kidney Precision Medicine Project and Single-Cell Biology of the Injured Proximal Tubule.肾脏精准医学项目与近端小管损伤的单细胞生物学
Am J Pathol. 2025 Jan;195(1):7-22. doi: 10.1016/j.ajpath.2024.09.006. Epub 2024 Sep 26.
2
Single-Cell Analysis Provides New Insights into the Roles of Tertiary Lymphoid Structures and Immune Cell Infiltration in Kidney Injury and Chronic Kidney Disease.单细胞分析为三级淋巴结构和免疫细胞浸润在肾损伤和慢性肾脏病中的作用提供了新见解。
Am J Pathol. 2025 Jan;195(1):40-54. doi: 10.1016/j.ajpath.2024.07.008. Epub 2024 Aug 7.
3
Single-Cell Advances in Investigating and Understanding Chronic Kidney Disease and Diabetic Kidney Disease.单细胞技术在研究和理解慢性肾脏病及糖尿病肾病中的进展
Am J Pathol. 2025 Jan;195(1):55-68. doi: 10.1016/j.ajpath.2024.07.007. Epub 2024 Aug 2.
4
Spatial Transcriptomics: Integrating Morphology and Molecular Mechanisms of Kidney Diseases.空间转录组学：整合肾脏疾病的形态学与分子机制
Am J Pathol. 2025 Jan;195(1):23-39. doi: 10.1016/j.ajpath.2024.06.012. Epub 2024 Aug 5.
5
Predicting proximal tubule failed repair drivers through regularized regression analysis of single cell multiomic sequencing.通过单细胞多组学测序的正则化回归分析预测近端肾小管修复失败的驱动因素。
Nat Commun. 2024 Feb 12;15(1):1291. doi: 10.1038/s41467-024-45706-0.
6
The chromatin landscape of healthy and injured cell types in the human kidney.人类肾脏中健康和受损细胞类型的染色质景观。
Nat Commun. 2024 Jan 10;15(1):433. doi: 10.1038/s41467-023-44467-6.
7
An atlas of healthy and injured cell states and niches in the human kidney.人类肾脏健康和损伤细胞状态及生态位图谱
Nature. 2023 Jul;619(7970):585-594. doi: 10.1038/s41586-023-05769-3. Epub 2023 Jul 19.
8
Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression.多模态单细胞测序提示染色质可及性和遗传背景在糖尿病肾病进展中的作用。
Nat Commun. 2022 Sep 6;13(1):5253. doi: 10.1038/s41467-022-32972-z.
9
Spatially resolved transcriptomics and the kidney: many opportunities.空间分辨转录组学与肾脏：机遇颇多。
Kidney Int. 2022 Sep;102(3):482-491. doi: 10.1016/j.kint.2022.06.011. Epub 2022 Jul 2.
10
Mapping the human kidney using single-cell genomics.单细胞基因组学绘制人类肾脏图谱。
Nat Rev Nephrol. 2022 Jun;18(6):347-360. doi: 10.1038/s41581-022-00553-4. Epub 2022 Mar 17.
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