Bokhman J V, Chepick O F, Volkova A T, Vishnevsky A S
Gynecol Oncol. 1985 Feb;20(2):139-55. doi: 10.1016/0090-8258(85)90135-0.
The data on 19 cases of primary endometrial carcinoma, stage I (mean age 28.0 years), cured by the administration of hydroxyprogesterone caproate without surgery and radiation therapy are presented. Clinical recovery in 15 cases was confirmed by repeated cytological and histological examinations of the endometrium. Hydroxyprogesterone caproate dose per course ranged within 25.0-83.0 g. In 4 patients with moderately differentiated cancer (G2), hormonal treatment was carried out in combination with chemotherapy. When tumor regression was confirmed histologically, steroid contraceptives were administered to induce an artificial menstrual cycle. At the closing stage of therapy clomiphene citrates were given in succession to restore the ovulatory cycle. Perspectives of administration of progestogens in young women with stage I endometrial carcinoma as a separate method of therapy are discussed.
本文报道了19例Ⅰ期原发性子宫内膜癌患者（平均年龄28.0岁），在未接受手术和放疗的情况下，通过使用己酸羟孕酮治愈的病例。通过对子宫内膜进行反复的细胞学和组织学检查，证实15例患者临床康复。每个疗程己酸羟孕酮的剂量范围为25.0 - 83.0 g。对于4例中分化癌（G2）患者，激素治疗与化疗联合进行。当组织学证实肿瘤消退时，给予甾体避孕药以诱导人工月经周期。在治疗末期，连续给予枸橼酸氯米芬以恢复排卵周期。本文还讨论了将孕激素作为Ⅰ期子宫内膜癌年轻女性的一种单独治疗方法的应用前景。
