Nabavi Seyed Salaheddin, Soheilipour Fahimeh, Delavar Motahare Aghajani, Javaherchian Mahsa, Karimian Pegah, Jafarnejad Shabahang, Ebrahimi Hamidreza Khoshnezhad, Mostafavi Atoosa, Dezfouli Seyedeh Mahsa Mahmoudinezhad, Esmaeilian Somayeh, Iranmanesh Saeideh
Department of General Surgery, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Pediatrics Endocrinology, School of Medicine, Iran University of Medical Sciences, Aliasghar Children Hospital, Tehran, Iran.
J Family Med Prim Care. 2024 Nov;13(11):4943-4948. doi: 10.4103/jfmpc.jfmpc_375_24. Epub 2024 Nov 18.
According to the role of 25-hydroxyvitamin D (25OHD) in glucose homeostasis and immune modulation, vitamin D deficiency may be associated with type 1 diabetes and diabetic ketoacidosis (DKA). Therefore, this study was conducted with the aim of investigation of the relationship between the vitamin D level and severity of diabetic ketoacidosis in new cases of type 1 diabetes in children referred to Hazrat-E-Ali-Asghar Hospital in 2021.
The present study is based on a cross-sectional study. The population studied in this research includes new cases of children with type 1 diabetes referred to Ali Asghar Children's Hospital in Tehran in 2021. The data analysis was performed using SPSS version 23 software and a significance level of less than 0.05 was considered.
In total, 112 people were included in the study. The difference between the three groups of severity of ketoacidosis in blood pH and bicarbonate level was significant ( < 0.001). The comparison of serum vitamin D levels in different severity of ketoacidosis showed a significant difference between the three groups ( = 0.013), which seems to be caused by the significant difference between the severe and mild ketoacidosis groups. There was observed no significant difference between the gender subgroups and different serum vitamin D levels and also different severity of ketoacidosis ( = 0.801) and ( = 0.25).
Based on the findings of our study, there is a significant relationship between vitamin D and the severity of diabetic ketoacidosis in children with type 2 diabetes. We suggest that routine evaluation of vitamin D levels in diabetic patients and prescribing vitamin D supplements to patients with vitamin D deficiency to prevent the risk of diabetic ketoacidosis.
鉴于25-羟基维生素D（25OHD）在葡萄糖稳态和免疫调节中的作用，维生素D缺乏可能与1型糖尿病及糖尿病酮症酸中毒（DKA）相关。因此，本研究旨在调查2021年转诊至哈扎特 - 阿里 - 阿斯加尔医院的1型糖尿病新发病儿童中维生素D水平与糖尿病酮症酸中毒严重程度之间的关系。
本研究为横断面研究。本研究的研究对象包括2021年转诊至德黑兰阿里·阿斯加尔儿童医院的1型糖尿病新发病儿童。使用SPSS 23版软件进行数据分析，显著性水平设定为小于0.05。
本研究共纳入112人。酮症酸中毒严重程度的三组在血pH值和碳酸氢盐水平上的差异具有显著性（<0.001）。不同严重程度酮症酸中毒患者血清维生素D水平的比较显示三组之间存在显著差异（=0.013），这似乎是由重度和轻度酮症酸中毒组之间的显著差异导致的。在性别亚组与不同血清维生素D水平以及不同酮症酸中毒严重程度之间未观察到显著差异（=0.801）和（=0.25）。
基于我们的研究结果，2型糖尿病儿童中维生素D与糖尿病酮症酸中毒的严重程度之间存在显著关系。我们建议对糖尿病患者进行维生素D水平的常规评估，并为维生素D缺乏的患者开具维生素D补充剂，以预防糖尿病酮症酸中毒的风险。
