Sokoloff L, Fincham J E, du Toit G T
Hum Pathol. 1985 Feb;16(2):117-20. doi: 10.1016/s0046-8177(85)80059-9.
Severe but atypical osteoarthritic deformities were found in each of 12 femoral heads removed during total hip arthroplasty for Mseleni disease. Although degenerative and regenerative changes were present throughout the cartilage, there was a paucity of eburnation. Histomorphometric analysis of bone at the line of excision indicated that mild osteomalacia was present in four of the 12 specimens. The percentage of the endosteum occupied by osteoid was 9.7 +/- 7.96 (SD) in the patients with Mseleni disease, compared with 5.6 +/- 4.33 in seven African black and 4.1 +/- 2.13 in 13 American white control subjects. The mean thickness of the osteoid seams was not increased. The findings suggest that osteomalacia is not a major pathogenetic factor in Mseleni disease.
在因姆塞莱尼病行全髋关节置换术而切除的12个股骨头中，均发现了严重但不典型的骨关节炎畸形。尽管整个软骨都存在退行性和再生性改变，但骨质象牙化现象并不明显。对切除线处的骨组织进行组织形态计量学分析表明，12个标本中有4个存在轻度骨软化。姆塞莱尼病患者骨内膜被类骨质占据的百分比为9.7±7.96（标准差），而7名非洲黑人对照组为5.6±4.33，13名美国白人对照组为4.1±2.13。类骨质缝的平均厚度并未增加。这些发现提示骨软化并非姆塞莱尼病的主要致病因素。
