Li Xiaotong, Lai Yaoyao, Wan Guanghan, Zou Jiahui, He Wei, Yang Pei
School of Pharmacy, China Pharmaceutical University, Nanjing 2111198, China.
School of Pharmacy, China Pharmaceutical University, Nanjing 2111198, China.
Chin J Nat Med. 2024 Dec;22(12):1100-1116. doi: 10.1016/S1875-5364(24)60726-0.
In recent years, there has been an increasing emphasis on exploring innovative drug delivery approaches due to the limitations of conventional therapeutic strategies, such as inadequate drug targeting, insufficient therapeutic efficacy, and significant adverse effects. Nanomedicines have emerged as a promising solution with notable advantages, including extended drug circulation, targeted delivery, and improved bioavailability, potentially enhancing the clinical treatment of various diseases. Natural products/materials-derived nanomedicines, characterized by their natural therapeutic efficacy, superior biocompatibility, and safety profile, play a crucial role in nanomedicine-based treatments. This review provides a comprehensive overview of currently approved natural products-derived nanomedicines, emphasizing the essential properties of natural products-derived drug carriers, their applications in clinical diagnosis and treatment, and the current therapeutic potential and challenges. The aim is to offer guidance for the application and further development of these innovative therapeutic approaches.
近年来，由于传统治疗策略存在局限性，如药物靶向性不足、治疗效果欠佳以及显著的不良反应，人们越来越重视探索创新的药物递送方法。纳米药物已成为一种有前景的解决方案，具有显著优势，包括延长药物循环时间、靶向递送和提高生物利用度，有可能增强各种疾病的临床治疗效果。天然产物/材料衍生的纳米药物，以其天然治疗功效、卓越的生物相容性和安全性为特征，在基于纳米药物的治疗中发挥着关键作用。本综述全面概述了目前已获批的天然产物衍生的纳米药物，强调了天然产物衍生药物载体的基本特性、它们在临床诊断和治疗中的应用以及当前的治疗潜力和挑战。目的是为这些创新治疗方法的应用和进一步发展提供指导。
